Treatment of cutaneous lupus erythematosus: current approaches and future strategies.

Current Opinion in Rheumatology
Hong ShiJ Michelle Kahlenberg

Abstract

Cutaneous lupus erythematosus (CLE) is a highly heterogeneous autoimmune disease. No specific Federal Drug Administration-approved therapies for CLE-alone are available, and resistance to conventional treatments is common. This review will summarize current treatment approaches and pending treatment strategies. Research into the pathogenesis of CLE is accelerating. A skewed type I interferon production and response contribute to CLE lesions. The pathophysiology of lesions may be similar among the lesional subtypes, and patients with a more TLR9-driven disease mechanism may have more benefit from hydroxychloroquine. Case reports continue to support the use of dapsone for CLE, especially bullous lupus erythematosus. Rituximab and Belimumab have efficacy in patients with systemic lupus erythematosus and severe active CLE. The significant role for type I interferons in CLE and encouraging clinical data suggest anifrolumab as a very promising agent for CLE. Dapirolizumab, BIIB059, Ustekinumab and Janus kinase inhibitors also have supportive early data as promising new strategies for CLE treatment. Continued research to understand the mechanisms driving CLE will facilitate the development and approval of new targets. The pipeline for...Continue Reading

References

Apr 28, 2010·Therapeutics and Clinical Risk Management·Christos E Lampropoulos, David P D'Cruz
Nov 19, 2013·Best Practice & Research. Clinical Rheumatology·L G Okon, V P Werth
May 17, 2014·Seminars in Arthritis and Rheumatism·Tatiana Cobo-IbáñezSantiago Muñoz-Fernández
Oct 3, 2014·JAMA Ophthalmology·Ronald B Melles, Michael F Marmor
Mar 20, 2016·Ophthalmology·Michael F MarmorUNKNOWN American Academy of Ophthalmology
Oct 7, 2016·PloS One·Ana Karina Alves de MedeirosJo Lambert
May 4, 2017·Expert Review of Clinical Immunology·Mariele GattoAndrea Doria
Oct 11, 2017·Journal of the American Academy of Dermatology·Lavanya MittalVictoria P Werth
Oct 11, 2017·Journal of the American Academy of Dermatology·François ChassetLaurent Arnaud
Oct 25, 2017·Journal of the American Academy of Dermatology·François ChassetCamille Francès
Jul 20, 2018·Annals of the Rheumatic Diseases·Mrinal K SarkarJ Michelle Kahlenberg
Aug 18, 2018·Expert Opinion on Biological Therapy·Oshrat E Tayer-ShifmanZahi Touma
Nov 2, 2018·JAMA Dermatology·Rita Quelhas da CostaAmanda M Saracino
Jan 8, 2019·Rheumatology·Evangelia Zampeli, Haralampos M Moutsopoulos
Jan 16, 2019·The Journal of Clinical Investigation·Richard FurieNathalie Franchimont
Feb 13, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lam C TsoiJ Michelle Kahlenberg
Mar 31, 2019·Annals of the Rheumatic Diseases·Antonis FanouriakisDimitrios T Boumpas
May 7, 2019·JAMA : the Journal of the American Medical Association·Murali K MattaDavid G Strauss
Jul 16, 2019·Journal of the American Academy of Dermatology·William D ShipmanJoseph L Jorizzo
Aug 21, 2019·Journal of Clinical Medicine·Celine C BerthierJ Michelle Kahlenberg
Sep 19, 2019·Seminars in Arthritis and Rheumatism·J L FairleyM Nikpour
Sep 19, 2019·Arthritis & Rheumatology·Michelle PetriDaniel W Goldman
Oct 22, 2019·Clinical, Cosmetic and Investigational Dermatology·Jaime Company-QuirogaAlberto Romero-Maté
Nov 7, 2019·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Emily Figueiredo Neves YukiSandra Gofinet Pasoto
Dec 19, 2019·The New England Journal of Medicine·Eric F MorandUNKNOWN TULIP-2 Trial Investigators

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Citations

Apr 4, 2020·The Journal of Rheumatology·Rosie ScuccimarriMary-Ann Fitzcharles
Jun 12, 2021·International Journal of Rheumatology·Elizabeth E CooperSamantha C Shapiro

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