Treatment of cutaneous lymphomas: an update

Actas dermo-sifiliográficas
R M Izu-Belloso, J C García-Ruiz

Abstract

Primary cutaneous lymphomas (PCLs) are a heterogeneous group of lymphoid tumors that originate primarily in the skin. Most PCLs (75%) are T-cell lymphomas and only 20% to 25% involve B cells. It is important to differentiate between cutaneous lymphomas and lymph node tumors given the differences in their molecular biology and clinical, histopathologic, and immunophenotypic features. Moreover, PCLs generally follow a more indolent course and require different treatments. Many treatment options are available for managing PLC's. The choice should be based primarily on the clinical stage of disease but must also take into consideration other factors, such as the patient's age and general health, the availability and accessibility of the treatment, and the cost-benefit ratio. It will be important to use a multidisciplinary approach, involving a team of expert dermatologists, hematologist-oncologists, and radiotherapists who are familiar with this rare disease. Recent years have seen the emergence of many new therapies, particularly for advanced stages of the disease and for patients whose tumors have proven refractory to treatment. The objective of this article is to review all the treatment options available to us.

References

May 1, 1990·Journal of the American Academy of Dermatology·H S ZackheimW R Crain
Apr 1, 1981·Journal of the American Academy of Dermatology·E A AbelR T Hoppe
Mar 1, 1994·International Journal of Radiation Oncology, Biology, Physics·G W JonesB Thorson
Dec 1, 1996·Journal of the American Academy of Dermatology·J A ZicL E King
Sep 2, 1998·Archives of Dermatology·H S ZackheimS Amin
Oct 27, 1998·International Journal of Radiation Oncology, Biology, Physics·B MicailyE C Vonderheid
Jan 8, 2000·Dermatologic Clinics·M Duvic, J C Cather
Jul 26, 2002·Journal of the American Academy of Dermatology·Raechele Cochran GathersHenry W Lim
Dec 23, 2003·Dermatologic Therapy·Herschel S Zackheim
Dec 23, 2003·Dermatologic Therapy·Elise A Olsen
Dec 31, 2003·The British Journal of Dermatology·S J WhittakerUNKNOWN U.K. Cutaneous Lymphoma Group
Apr 2, 2004·Expert Review of Anticancer Therapy·Len T Farol, Kenneth B Hymes
Oct 20, 2004·Archives of Dermatology·Thierry PasseronJean-Paul Ortonne
Feb 5, 2005·Blood·Rein WillemzeChris J L M Meijer
Mar 7, 2006·Seminars in Oncology·Francine Foss
Apr 1, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Franz TrautingerSean Whittaker
Apr 12, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sandra J StraussT Andrew Lister
Aug 2, 2006·Clinical Lymphoma & Myeloma·Madeleine DuvicNarin Apisarnthanarax
Aug 3, 2006·The British Journal of Dermatology·C AssafS Whittaker
Aug 11, 2006·Journal of the European Academy of Dermatology and Venereology : JEADV·G GökdemirA Köşlü
Jun 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Elise A OlsenMadeleine Duvic
Jun 28, 2007·Expert Opinion on Investigational Drugs·Madeleine Duvic, Jenny Vu
Aug 21, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R DummerS Whittaker
Aug 22, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Pier Luigi ZinzaniMichele Baccarani
Nov 21, 2007·Clinical Lymphoma & Myeloma·Tanya HathawayFrancine Foss
May 27, 2008·Clinical Lymphoma & Myeloma·Kelley VidulichMadeleine Duvic
Aug 8, 2008·Future Oncology·Madeleine Duvic, Rakhshandra Talpur
Aug 15, 2008·Biotechnology Journal·Sigrid R RuulsPaul W H I Parren
Oct 4, 2008·Dermatology : International Journal for Clinical and Investigative Dermatology·Olivier DereureBernard Guillot
Oct 10, 2008·Journal of the American Academy of Dermatology·Joi Carter, Kathryn A Zug
Dec 17, 2008·Clinical Lymphoma & Myeloma·Steven M Horwitz
Feb 19, 2009·The British Journal of Dermatology·R A AbbottJ J Scarisbrick
Jun 18, 2009·Current Opinion in Oncology·Jennifer M GardnerEllen J Kim
Jun 23, 2009·Journal of the American Academy of Dermatology·Jennifer M GardnerAlain H Rook

❮ Previous
Next ❯

Citations

Jan 24, 2013·Actas dermo-sifiliográficas·A Santamarina-AlbertosA Miranda-Romero
May 12, 2015·Actas dermo-sifiliográficas·E del Alcázar-ViladomiuM J Vidal-Manceñido
Jan 11, 2018·International Journal of Dermatology·Gustavo M AmorimMarcia Ramos-E-Silva

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.