Treatment of cyclosporin-induced gingival hyperplasia with azithromycin

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
E GómezJ Alvarez-Grande

Abstract

Gingival hyperplasia is a known complication of cyclosporin therapy. Although plaque control has been shown to be of benefit, gingival surgery is occasionally necessary. The aim of this study was to review the effect of a short-course therapy with azithromycin in renal transplant patients with cyclosporin-induced gingival hyperplasia. Thirty-eight patients received 500 mg/day of azithromycin for 3 consecutive days. The degree of gingival hyperplasia was classified as: 0, no gingival overgrowth; 1, mild overgrowth; 2, moderate overgrowth, and 3, severe overgrowth. Gingival bleeding and evolution of gingival hyperplasia were determined at 0 (pretreatment), 7, 30, 90 and 180 days. Cyclosporin, serum creatinine and ALT levels were simultaneously determined on the same days. Seven patients were excluded, leaving a total of 31 included in the trial. Eleven had a score of 3, 17 a score of 2, and 3 a score of 1. The degree of gingival hyperplasia was unrelated to the dose and levels of cyclosporin. Gingival hyperplasia improved in all patients (P < 0.001, Friedman test). The degree of improvement was better when the degree of hyperplasia was lower. In 27 patients gingival hyperplasia remained absent 6 months later, 3 patients required ...Continue Reading

Citations

Mar 12, 2005·Journal of the American Academy of Dermatology·Pooja KheraJoseph C English
May 7, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Harald C WormHerwig Holzer
Nov 26, 2004·Journal of Periodontology·Anna Dongari-Bagtzoglou, UNKNOWN Research, Science and Therapy Committee, American Academy of Periodontology
Jan 1, 2011·Case Reports in Dentistry·Bien LaiMichael W Roberts
Apr 26, 2013·Clinical and Experimental Nephrology·Kanika KapoorN K Dubey
Nov 24, 2012·Dental Clinics of North America·H Jung Song
Mar 10, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Swati ChoudhryAmit Dinda
Jul 1, 2008·Transplantation Proceedings·S A P CondéM G Bastos
Jul 2, 2003·International Journal of Paediatric Dentistry·D ChabriaN M Kilpatrick
Feb 19, 2009·The Journal of Clinical Hypertension·Costas Fourtounas, Jannis G Vlachojannis
Nov 5, 2011·Journal of Periodontal Research·R HirschM N Laohachai
Sep 26, 2006·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Indraneel BhattacharyyaDonald M Cohen
Oct 24, 2008·Journal of Dental Research·J-Y KimW-Y Chung
Feb 20, 2020·Clinical Advances in Periodontics·Satish S KumarKian Kar
May 8, 2002·Progress in Transplantation : Official Publication, North American Transplant Coordinators Organization ... [et Al.]·Kerri A Hood
Oct 1, 2004·Journal of Periodontology

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
M L Sánchez-NuñezJ Alvarez-Grande
© 2021 Meta ULC. All rights reserved