Treatment of Darier's disease with oral magnesium: a case report

SAGE Open Medical Case Reports
Heidi Oi-Yee LiNordau Kanigsberg

Abstract

Darier's disease, an autosomal dominant genodermatosis, arises from a mutation in the ATP2A2 gene that codes for sarco/endoplasmic reticulum Ca2+-ATPase in the endoplasmic reticulum and is characterized by greasy keratotic papules commonly found in seborrheic regions. Conventional treatments, including topical corticosteroids, antibiotics, antifungals and retinoids, often have limited efficacy. The present article reports the novel use of oral magnesium chloride supplementation (300 mg daily) in the treatment of Darier disease. After 5 years of limited improvement using conventional therapies, significant improvements in neck lesions were observed within 1 month of starting oral magnesium chloride. This suggests that oral magnesium chloride may be an effective therapeutic option for Darier disease, although further in vitro and clinical trials are necessary to evaluate its clinical efficacy.

References

Dec 1, 2007·Cellular and Molecular Life Sciences : CMLS·B Pani, B B Singh
Mar 8, 2016·The Journal of Dermatology·Atsushi TakagiShigaku Ikeda

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Citations

Feb 14, 2021·Indian Journal of Dermatology, Venereology and Leprology·Roger N Haber, Nicole G Dib
Nov 30, 2021·Journal of Cutaneous Medicine and Surgery·N HannaC Lynde

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Methods Mentioned

BETA
biopsy

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