PMID: 9444543Jan 28, 1998Paper

Treatment of depression in the elderly: effect of physical illness on response

International Journal of Geriatric Psychiatry
M E EvansJ Copeland

Abstract

To determine the response to treatment of different subgroups within a sample of physically ill elderly depressed patients. Acute geriatric medical inpatients with depression, randomly assigned to an 8-week double-blind placebo-controlled trial of fluoxetine. Response rate as defined by the 17-item Hamilton Depression Rating Scale. Data were analysed in subgroups according to diagnosed physical problems and concomitant medication. A logistic regression analysis was performed to identify subgroups valid for separate analysis. Those reaching at least 5 weeks of treatment showed a significant improvement compared with the placebo group if they had serious life-threatening disease, cerebrovascular disease, were not demented, or were either on no analgesics or on analgesics stronger than paracetamol. While the response to treatment in these subgroups was encouraging, general physicians must not be led to believe that the answer to depression lies only in pharmacological intervention, just as the belief that the risk-benefit ratio of such treatment where indicated is too high must be discouraged.

Citations

Jul 9, 1999·International Journal of Geriatric Psychiatry·T StevensG Livingston
Dec 23, 2003·Journal of the American Geriatrics Society·Javaid I SheikhTal Burt
Sep 21, 2005·Journal of Clinical Pharmacology·Francis E Lotrich, Bruce G Pollock
May 15, 2004·Current Psychiatry Reports·Dan V IosifescuMaurizio Fava
Jun 26, 2007·International Journal of Clinical Practice·T N WiseJ Raskin
Sep 24, 2008·Drugs & Aging·Tarek K RajjiCharles F Reynolds
Aug 13, 2009·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Anna PlacentinoJorge Perez
Jan 29, 2020·The Cochrane Database of Systematic Reviews·Sabine AllidaMaree L Hackett
Jun 19, 2001·The Cochrane Database of Systematic Reviews·K WilsonA Nightingale
Oct 10, 2008·The Cochrane Database of Systematic Reviews·Maree L HackettJun Xia

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