PMID: 8601647Apr 1, 1996Paper

Treatment of dermatophyte nail infections: an open randomized study comparing intermittent terbinafine therapy with continuous terbinafine treatment and intermittent itraconazole therapy

Journal of the American Academy of Dermatology
A TostiM D Colombo

Abstract

terbinafine persists in the nail at effective concentrations for several weeks after discontinuation of treatment. Our purpose was to verify whether intermittent terbinafine therapy is effective in dermatophytic onychomycosis and to compare the results of intermittent terbinafine with those of intermittent itraconazole and continuous terbinafine treatment. An open, randomized study of 63 patients was performed with three treatment regimens: terbinafine, 250 mg daily (21 patients); terbinafine, 500 mg daily for 1 week every month (21 patients); or itraconazole, 400 mg daily for 1 week every month (21 patients). Treatment was continued for 4 months in toenail infections (60 patients) and 2 months in fingernail infections (3 patients). At the end of the follow-up period (6 months after discontinuation of treatment) 16 of the 17 patients (94.1%) with toenail onychomycosis were mycologically cured in the terbinafine 250 mg group, 16 of 20 (80%) in the terbinafine 500 mg group, and 15 of 20 (75%) in the itraconazole group. The percentage of patients who were mycologically cured was higher in the continuous terbinafine group than in the intermittent terbinafine and itraconazole groups, but statistical analysis did not reveal any signi...Continue Reading

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Citations

Dec 22, 1999·Journal of the American Academy of Dermatology·B E Elewski
Dec 20, 2002·Clinics in Dermatology·Joseph Obadiah, Richard Scher
Mar 5, 2003·Journal of Diabetes and Its Complications·Jeffrey M Robbins
Oct 9, 1999·International Journal of Dermatology·J E ArreseG E Piérard
Oct 9, 1999·International Journal of Dermatology·A K Gupta, J Lambert
Aug 12, 2000·International Journal of Dermatology·A K GuptaH Degreef
Feb 27, 1999·The Pediatric Infectious Disease Journal·S F Friedlander
Jun 1, 1996·The British Journal of Dermatology·A Rashid
Feb 13, 2004·Drugs & Aging·James S Tan, Warren S Joseph
Jul 28, 2001·Clinical Pharmacokinetics·D Debruyne, A Coquerel
Feb 24, 2001·Drugs·J F Meis, P E Verweij
Dec 12, 2001·PharmacoEconomics·V N Joish, E P Armstrong
Jan 31, 2002·American Journal of Clinical Dermatology·Annarosa VirgiliLucia Mantovani
Jun 10, 2004·American Journal of Clinical Dermatology·W Philip WerschlerDavid Armstrong
Dec 20, 2013·American Journal of Clinical Dermatology·Daniel Coelho de SáAntonella Tosti
May 27, 2004·The Journal of Dermatology·Akira KawadaTadashi Tezuka
May 15, 2009·Journal of the European Academy of Dermatology and Venereology : JEADV·A K GuptaE A Cooper
May 29, 2012·Journal of the European Academy of Dermatology and Venereology : JEADV·A K GuptaA Tavakkol
Jun 15, 2011·Mycoses·Lauren Van Duyn Graham, Boni E Elewski
Sep 4, 2007·The American Journal of Medicine·Chia-Hsuin ChangArnold K Chan
Jan 7, 1998·Journal of the American Academy of Dermatology·P D DonckerA Heremans
Jan 7, 1998·Journal of the American Academy of Dermatology·A K Gupta, N H Shear
May 3, 2000·Dermatologic Clinics·A Tosti, B M Piraccini
May 1, 2012·Mycoses·Chander Grover, Ananta Khurana
Jun 19, 2015·Indian Journal of Dermatology, Venereology and Leprology·Pravesh YadavShukla Das
Nov 22, 2005·Expert Opinion on Drug Delivery·Matilde IorizzoAntonella Tosti
Sep 17, 2004·The Journal of Dermatological Treatment·F PavlotskyH Trau
Aug 19, 2005·Expert Review of Anti-infective Therapy·Adolfo C Fernandez-ObregonCarolyn Willis
Feb 10, 2006·The Journal of Dermatological Treatment·Bardur SigurgeirssonRajesh Bakshi
Mar 13, 1998·The Annals of Pharmacotherapy·E F Trépanier, G W Amsden
Jun 18, 2016·Journal of Cutaneous Medicine and Surgery·Aditya K GuptaKelly A Foley
Jun 6, 2002·School Nurse News
Jun 19, 2003·Photochemistry and Photobiology·Threes G M Smijs, Hans J Schuitmaker
Mar 24, 2000·The British Journal of Dermatology·D T Roberts
Sep 5, 2001·The British Journal of Dermatology·B J Cribier, C Paul
Jul 15, 2017·The Cochrane Database of Systematic Reviews·Sanne Kreijkamp-KaspersMieke L van Driel
Jul 25, 2003·Journal of Cutaneous Medicine and Surgery·Aditya K GuptaRichard C Summerbell
Nov 26, 2002·Journal of Cutaneous Medicine and Surgery·Hugo Néstor Cabrera, María Luisa Gómez
Mar 26, 2003·The British Journal of Dermatology·D T RobertsUNKNOWN British Association of Dermatologists

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