Treatment of diabetic dyslipidemia

The American Journal of Cardiology
A Garg

Abstract

Patients with diabetes mellitus have an increased risk for coronary artery disease due to hyperglycemia, hypertension, dyslipidemia, and other risk factors. The diabetic dyslipidemia in these patients is characterized by moderately high levels of (1) serum cholesterol and triglycerides; (2) small, dense low-density lipoprotein (LDL) particles; and (3) low high-density lipoprotein (HDL) cho-lesterol concentrations. Recent clinical trials have demonstrated the benefits of cholesterol-lowering therapy in both diabetic and nondiabetic patients, thus supporting aggressive treatment of diabetic dyslipidemia for coronary artery disease prevention. A 3-step approach is recommended for the treatment of diabetic dyslipidemia. First, modification of diet and lifestyle, including decreased intakes of cholesterol, cholesterol-raising fats, and total energy, and increased physical activity should be advised. Second, good glycemic control should be achieved with diet and hypoglycemic drugs, if needed. Third, lipid-lowering drugs should be used, if necessary. Non-HDL cholesterol levels, which include both very-low-density lipoprotein (VLDL) and LDL cholesterol, should be the target of cholesterol-lowering therapy. The use of 3-hydroxy-3-methyl...Continue Reading

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Citations

Oct 16, 2012·Current Cardiology Reports·W M Monique Verschuren
Jul 18, 2001·Journal of Diabetes and Its Complications·J A PapadakisD P Mikhailidis
Nov 13, 2001·Diabetes, Obesity & Metabolism·D C FelmedenG Beevers
Jan 25, 2011·Cardiology Clinics·Sundararajan Srikanth, Prakash Deedwania
Jan 20, 2009·Heart & Lung : the Journal of Critical Care·Xingang ZhangYingxian Sun
Mar 14, 2014·Global Change Biology·Balathandayuthabani Panneer SelvamDavid Bastviken
Feb 8, 2005·Cardiology Clinics·Sundararajan Srikanth, Prakash Deedwania
Jul 25, 2003·Diabetes/metabolism Research and Reviews·Steven M Haffner
Jan 20, 2004·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Odd E Johansen, Kåre I Birkeland
Feb 1, 2000·The Journal of Cardiovascular Nursing·C Lamendola
Feb 1, 2000·The Journal of Cardiovascular Nursing·M Gulanick, L A Cofer
Jan 5, 2002·Current Atherosclerosis Reports·Ouliana ZiouzenkovaJorge Plutzky

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