Treatment of diabetic foot ulcers with hyperbaric oxygen

Journal of Wound Care
C Senior

Abstract

The delivery of oxygen to the wound site is crucial in healing diabetic foot ulcers, and impairment of this process in people with diabetes leads to delayed wound repair. Hyperbaric oxygen therapy works by elevating the plasma oxygen level. Fibroblasts synthesise and modify collagen, and both these activities require relatively high partial pressures of oxygen. Hyperbaric oxygen can promote healing by stimulating fibroblast activity and collagen formation. Increasing oxygen tensions also has a direct and toxic effect on anaerobes, therefore hyperbaric oxygen therapy has a special role in treating diabetic foot infections. Studies on hyperbaric oxygen therapy in general show it to be a beneficial adjunctive therapy for diabetic foot ulcers. However much of the work is anecdotal and more controlled trials are required.

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Citations

Apr 12, 2014·The Journal of Surgical Research·Ching-Jen WangYur-Ren Kuo
Jul 12, 2011·Diabetes Research and Clinical Practice·Ching-Jen WangYa-Ju Yang
Feb 19, 2008·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Bülent KurtOmer Günhan
Sep 11, 2007·Infectious Disease Clinics of North America·Smita GuptaNancy Khardori
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Aug 27, 2009·Nursing in Critical Care·Daniela LehwaldtSheila O'Connor
Sep 3, 2013·The Medical Clinics of North America·Magnus Löndahl
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Apr 6, 2002·Journal of Wound Care·J Fawcett

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