Treatment of diffuse large B-cell lymphoma in the elderly: strategies integrating oncogeriatric themes.

Current Oncology Reports
Pieternella Johanna Lugtenburg, Pieter Sonneveld

Abstract

With an increasingly aged population, many patients will present with diffuse large B-cell lymphoma in their 70s and 80s. Recently, several randomized studies have confirmed the benefit of rituximab in combination with CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) and showed a substantial improvement in the outcome of fit elderly patients. This article reviews the efficacy and toxicity of the current treatment regimens applied for the treatment of diffuse large B-cell lymphoma in elderly patients and provides practical recommendations for the management of these patients.

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Citations

Jan 25, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E WeidmannE Jäger
Apr 8, 2010·Clinical Lymphoma, Myeloma & Leukemia·Agustin AvilésMaría de Jesús Nambo
Apr 1, 2009·Expert Review of Hematology·Mary J Ninan, Vicki A Morrison

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