Treatment of dilated cardiomyopathy in rabbits with mesenchymal stem cell transplantation and platelet-rich plasma

The Veterinary Journal
P D MörschbächerE Cirne-Lima

Abstract

Dilated cardiomyopathy (DCM) is a major cause of cardiovascular mortality and morbidity, and there is evidence to suggest that stem cell transplantation may be a viable treatment option for this condition. Therefore, the goal of the present study was to assess myocardial regeneration in rabbits with doxorubicin-induced DCM treated with adipose mesenchymal stem cells (MSC) alone or in combination with platelet-rich plasma (PRP). Twenty New Zealand rabbits received doxorubicin for the induction of DCM and were divided into four groups according to treatment: saline, MSC, PRP and MSC + RP. Treatment agents were injected directly into the left ventricular myocardium following a thoracoscopy. Rabbits were assessed through echocardiographic and electrocardiographic examinations, as well as serum cardiac troponin I measurements at baseline, after the induction of DCM and 15 days after treatment. Animals were euthanased following the last assessment, and hearts were collected for histopathological analyses. The MSC group showed improvements in all parameters assessed, while the PRP group showed significantly impaired heart function. Histopathology of the heart revealed that the MSC group displayed the lowest number of lesions, while ra...Continue Reading

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Citations

Feb 7, 2018·Stem Cell Research & Therapy·Danúbia Silva Dos SantosRegina Coeli Dos Santos Goldenberg
Oct 12, 2019·Journal of Tissue Engineering and Regenerative Medicine·David ScullyAntonios Matsakas
Nov 26, 2020·Acta Cirúrgica Brasileira·Raquel de Oliveira MeiraLuiz Ronaldo Alberti
Aug 12, 2019·Biochemical and Biophysical Research Communications·Haihong LinHui Gong

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