PMID: 11914154Mar 27, 2002Paper

Treatment of disseminated granuloma annulare with fumaric acid esters

BMC Dermatology
A KreuterNorbert H Brockmeyer

Abstract

Granuloma annulare is a granulomatous disease of unknown etiology. Various therapies have been tried in disseminated granuloma annulare (DGA), including corticosteroids, several variants of psoralen plus ultraviolet-A radiation, ultraviolet- A1 radiation, systemic retinoids, and dapsone, with variable success. We report a patient with recalcitrant DGA who was treated with fumaric acid esters (FAE). A 40-year old Caucasian woman presented with a 25-year history of recalcitrant DGA. On both legs and the abdomen there were erythematous annular plaques. She was treated with FAE in tablet form using two formulations differing in strength (low strength tablets: 30 mg dimethylfumarate, 67 mg monoethylfumarate Ca salt, 5 mg monoethylfumarate Mg salt, 3 mg monoethylfumarate Zn salt; high strength tablets: 120 mg dimethylfumarate, 87 mg monoethylfumarate Ca salt, 5 mg monoethylfumarate Mg salt, 3 mg monoethylfumarate Zn salt). After three-month therapy, an almost complete clearance of skin lesions was achieved. With the exception of temporary lymphopenia, no adverse effects were observed. The patient remained in remission during a six-month follow up period. Our observation has demonstrated that FAE is a potentially beneficial therapeuti...Continue Reading

References

Jan 1, 1989·Journal of the American Academy of Dermatology·K Dabski, R K Winkelmann
Jun 1, 1994·Journal of the American Academy of Dermatology·P J AltmeyerG Lutz
Feb 1, 1996·Journal of the American Academy of Dermatology·A M Skaria, U Schmid
May 1, 1997·International Journal of Dermatology·M D SmithD DiCostanzo
Jan 8, 1998·Archives of Dermatology·S MuchenbergerJ C Simon
Jun 4, 1999·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·N SalomonM Röcken
Feb 17, 2001·The Journal of Investigative Dermatology·K Zhu, U Mrowietz
Apr 4, 2001·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·A Schulze-Dirks, D Petzoldt

❮ Previous
Next ❯

Citations

Jun 14, 2005·The British Journal of Dermatology·K BreuerT Werfel
Sep 27, 2005·The British Journal of Dermatology·A KreuterT Gambichler
Nov 10, 2005·Proceedings·Jennifer Clay Cather, John Christian Cather
Mar 24, 2005·Dermatology : International Journal for Clinical and Investigative Dermatology·B Eberlein-KönigD Abeck
May 23, 2013·American Journal of Clinical Dermatology·Laura A Thornsberry, Joseph C English
Oct 20, 2011·Journal of the European Academy of Dermatology and Venereology : JEADV·A KleinP Babilas
Apr 18, 2013·International Journal of Dermatology·Udaya Acharya

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Dermatology : International Journal for Clinical and Investigative Dermatology
B Eberlein-KönigD Abeck
The Annals of Pharmacotherapy
Claudia H GuentherMichael Meurer
© 2022 Meta ULC. All rights reserved