Treatment of drug-resistant Aspergillus infection

Expert Opinion on Pharmacotherapy
Maria Aigner, Cornelia Lass-Flörl

Abstract

Triazole antifungals are frontline drugs for the treatment and prophylaxis of infections due to Aspergillus species. Azole resistance is an emerging problem and is associated with treatment failure in several case series. The management of azole-resistant invasive aspergillosis remains a challenge and there are no guidelines with appropriate recommendations. The current clinical practice suggests that liposomal amphotericin B or a combination of voriconazole or posaconazole with an echinocandin may be effective. Although cross-resistance within the azoles seems to be common, the role of azoles in the management of azole-resistant aspergillosis remains unclear, but optimizing drug exposure is critical for treatment success.

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Citations

Feb 18, 2016·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·He WangYing-Chun Xu
Jul 1, 2016·Current Fungal Infection Reports·Bart G J DekkersJan-Willem C Alffenaar
Jun 30, 2016·Expert Review of Anti-infective Therapy·Kathleen M JobCatherine M T Sherwin
Apr 22, 2017·Expert Opinion on Biological Therapy·Wilfried PoschCornelia Lass-Flörl
Feb 27, 2017·Drugs·Rocio Garcia-RubioEmilia Mellado
Jul 30, 2020·Antibiotics·Gina Wall, Jose L Lopez-Ribot
Nov 2, 2019·MSphere·Suresh AmbatiRichard B Meagher
Jun 16, 2021·Expert Opinion on Pharmacotherapy·Shirisha Pasula, Pranatharthi H Chandrasekar

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Aspergillosis (ASM)

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Aspergillosis

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

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