Treatment of Dry Eye from Laser-Assisted In Situ Keratomileusis With Recombinant Human Nerve Growth Factor (Cenegermin).

Cornea
Roya N Habibi, Michele D Lee

Abstract

To describe 2 patients with neurotrophic keratitis after laser-assisted in situ keratomileusis surgery who were treated with recombinant human nerve growth factor (cenegermin) and the treatment course. Case series. After an 8 week course of cenegermin, there was an improvement in visual acuity, corneal sensitivity, and ocular surface staining. However, these effects were short lived, and the disease regressed at subsequent follow-up visits. Although recombinant human nerve growth factor seems to be effective in short term for neurotrophic keratitis secondary to laser-assisted in situ keratomileusis surgery, alternative dosing for patients with this patient population should be considered to achieve long-lasting resolution.

References

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Oct 27, 2004·Investigative Ophthalmology & Visual Science·Martha P CalvilloWilliam M Bourne
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Jan 21, 2014·The Ocular Surface·Cecilia ChaoFiona Stapleton
Apr 15, 2018·Ophthalmology·Stefano BoniniUNKNOWN REPARO Study Group
Aug 14, 2019·Cornea·Emilio PedrottiGiorgio Marchini

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