PMID: 6108607Jan 1, 1980Paper

Treatment of duodenal ulcer with ranitidine, a new histamine H2-receptor antagonist

Scandinavian Journal of Gastroenterology
A BerstadA Kruse-Jensen

Abstract

Fifty patients with endoscopically verified duodenal ulcer were treated with either 100 mg of ranitidine hydrochloride (corresponding to 89.4 mg of ranitidine base) or identical placebo tablets twice daily under double-blind conditions. One patient did not attend for the second endoscopy and was excluded. Endoscopic examination after 4 weeks of treatment showed that the ulcer had healed in 23 out of 25 patients (92%) treated with ranitidine and in 11 out of 24 patients (46%) treated with placebo (P < 0.01). The ranitidine-treated patients had significantly less ulcer symptoms during treatment. Antacid consumption was also less in the ranitidine than in the placebo-treated group, but the difference was not significant. After 4 weeks in the double-blind study 14 of the 15 patients with unhealed ulcer received open treatment with ranitidine for 4-6 weeks. The ulcer healed in all but one patient. No serious side effects of ranitidine were observed.

References

Jan 1, 1980·Scandinavian Journal of Gastroenterology·K KettA Berstad
Mar 1, 1980·Gut·E P WoodingsD A Richards

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Citations

Aug 1, 1982·Digestive Diseases and Sciences·M G KormanG T Schmidt
Aug 1, 1991·Controlled Clinical Trials·A L Gould
Dec 1, 1983·The New England Journal of Medicine·J B ZeldisK J Isselbacher
Feb 13, 1982·British Medical Journal·M G AshtonM Moore
Feb 1, 1983·Postgraduate Medical Journal·F I LeeF T Costello
Oct 29, 2011·Naunyn-Schmiedeberg's Archives of Pharmacology·Heidrun ApplRoland Seifert
Mar 1, 1983·Journal of Clinical and Hospital Pharmacy·J DawsonR Cockel
Mar 25, 2015·Scandinavian Journal of Gastroenterology·Lars Aabakken
Jan 1, 1990·International Journal of Psychiatry in Medicine·R M Leipzig
Jul 12, 1980·British Medical Journal
Oct 1, 1982·Australian and New Zealand Journal of Medicine·D B JonesR A Smallwood
Oct 1, 1982·Scandinavian Journal of Gastroenterology·A BerstadJ Aaseth
Nov 1, 1985·Scandinavian Journal of Gastroenterology·R WebergE Aubert
Sep 1, 1981·The Journal of Pharmacy and Pharmacology·A H Robins, M L McFadyen
Jan 1, 1983·The Journal of International Medical Research·H BrunnerR Pötzi
Dec 31, 2002·The Annals of Pharmacotherapy·Jay S Cohen
Mar 1, 1986·American Journal of Surgery·H T Debas, M W Mulholland

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