Treatment of dwarfism with recombinant human insulin-like growth factor-1.

Deutsches Ärzteblatt International
Michael B RankeMarkus Bettendorf

Abstract

The growth hormone-IGF (insulin-like growth factor) system plays a central role in hormonal growth regulation. Recombinant human (rh) growth hormone (GH) has been available since the late 1980s for replacement therapy in GH-deficient patients and for the stimulation of growth in patients with short stature of various causes. Growth promotion by GH occurs in part indirectly through the induction of IGF-1 synthesis. In primary disturbances of IGF-1 production, short stature can only be treated with recombinant human IGF-1 (rhIGF-1). rhIGF-1 was recently approved for this indication but can also be used to treat other conditions. Selective review of the literature on IGF-1 therapy, based on a PubMed search. In children with severe primary IGF-1 deficiency (a rare condition whose prevalence is less than 1:10,000), the prognosis for final height is very poor (ca. 130 cm), and IGF-1 therapy is the appropriate form of pathophysiologically based treatment. There is no alternative treatment at present. The subcutaneous administration of IGF-1 twice daily in doses of 80 to 120 microg/kg accelerates growth and increases final height by 12 to 15 cm, according to current data. There is, however, a risk of hypoglycemia, as IGF-1 has an insul...Continue Reading

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Citations

Jan 12, 2013·Orphanet Journal of Rare Diseases·Sarah C GrünertJörn Oliver Sass
Oct 23, 2012·Indian Journal of Endocrinology and Metabolism·Laxminarasimhan BalajiPalanisamy Soundararajan
Jan 24, 2013·The Journal of Clinical Endocrinology and Metabolism·Jaime Guevara-AguirrePatricio Procel
Jul 12, 2018·Journal of Pediatric Endocrinology & Metabolism : JPEM·Thomas BreilJoachim Woelfle
Apr 27, 2018·International Journal of Molecular Sciences·Michaela PlamperJoachim Woelfle

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