PMID: 11320900Apr 26, 2001Paper

Treatment of elderly patients with intermediate- and high-grade non-Hodgkin's lymphoma: a retrospective population-based study

Annals of Hematology
F P PetersH C Schouten

Abstract

Nowadays more people are becoming older. The median age of a patient with non-Hodgkin's lymphoma (NHL) at diagnosis is over 60 years. The incidence of NHL in elderly has increased in the last decades. Therefore, in the future, NHL will be diagnosed more often in the elderly. Data of all patients in the south-east of the Netherlands with newly diagnosed NHL between January 1991 and January 1995 were analysed in a retrospective multicentre population-based study to investigate if and how elderly patients (> 60 years) with advanced NHL (Ann Arbor Staging > or = IIB) of intermediate- and high-grade malignancy were treated. Treatment modalities applied, outcome, and causes of death were evaluated. Treatment was considered inadequate if it deviated from the standard anthracycline-containing chemotherapy (CNOP/CHOP) for a minimum of six cycles. The entry criteria were met by 68 patients. Of these patients, 57 (83.8%) were treated and 11 (16.2%) were not treated. The treatment consisted of CHOP (36 patients), CNOP (6 patients), chlorambucil (13 patients), or COP (2 patients). Forty-two of 68 patients had adequate treatment, but 14 of 42 (33.3%) patients had a suboptimal numbers of cycles (< 6). Of 28 patients with adequate chemotherapy...Continue Reading

Citations

Aug 16, 2002·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E WeidmannP S Mitrou
Sep 29, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S A M van de SchansM L G Janssen-Heijnen
Jun 2, 2014·European Journal of Internal Medicine·S DiemF Hitz
May 24, 2011·Leukemia & Lymphoma·Erika Ramsdale, Sonali Smith
Jul 16, 2005·Leukemia & Lymphoma·Linda Mileshkin, H Miles Prince
Apr 15, 2015·Annals of Hematology·M W M van der PoelH C Schouten
Aug 28, 2004·Critical Reviews in Oncology/hematology·Lucia Fratino, Daniele Bernardi
May 10, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Catherine Thieblemont, Bertrand Coiffier
Jul 2, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Dawn L HershmanJudith S Jacobson
Jan 23, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Clémentine Sarkozy, Bertrand Coiffier
Mar 2, 2006·Annals of Oncology : Official Journal of the European Society for Medical Oncology·O BaireyR Ruchlemer
May 1, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S A M van de SchansM L G Janssen-Heijnen
Mar 23, 2010·Critical Reviews in Oncology/hematology·A GutiérrezJ Rodríguez

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