Treatment of Elizabethkingia meningoseptica Neonatal Meningitis with Combination Systemic and Intraventricular Therapy

Indian Journal of Pediatrics
Preetha JoshiTanu Singhal

Abstract

Elizabethkingia meningoseptica, a gram negative bacillus ubiquitous in the hospital environment, is known to infrequently cause serious neonatal infections, particularly meningitis which is associated with high mortality and neuromorbidity in survivors. The authors describe a healthy term newborn with no apparent risk factors who developed Elizabethkingia meningoseptica sepsis and meningitis on day 6 of life. Diagnosis could be established only after a week of the illness by which time the baby developed refractory status epilepticus, ventriculitis and hydrocephalus. The isolate was susceptible to only ciprofloxacin, tigecycline and rifampicin and resistant to vancomycin. Apart from systemic combination therapy for 12 wk, intraventricular vancomycin was given through an external ventricular drain for 4 wk and later a ventriculo-peritoneal (VP) shunt was inserted. With this regime, authors demonstrated microbiologic and clinical cure. The baby is neurologically normal over a 6 mo follow-up.

References

Oct 21, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Allan R TunkelRichard J Whitley
Jun 28, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Allan R TunkelUNKNOWN Infectious Diseases Society of America
Apr 5, 2011·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M-S HsuP-R Hsueh
Jul 15, 2017·International Journal of Antimicrobial Agents·Shio-Shin JeanPo-Ren Hsueh
Dec 7, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Eric J DziubanDavid D Blaney

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