Treatment of endotoxic shock: glucocorticoids, lazaroids, nonsteroidals, others

The Veterinary Clinics of North America. Small Animal Practice
L M Howe

Abstract

Review of the literature would indicate that a therapy inhibiting a single step in the inflammatory mediator cascade, although potentially beneficial, cannot serve as the "magic bullet" in endotoxic shock. Thus, combination therapy using drugs that target multiple steps in the mediator cascade may prove useful in the future. Until controlled clinical studies have been performed in veterinary medicine using the agents discussed in this manuscript (or others), many questions will remain regarding the best possible pharmacologic therapies to use in supplementing traditional supportive care (e.g., fluids, broad-spectrum antimicrobials) measures. Many of the therapies discussed in this manuscript hold tremendous potential, but must be administered before endotoxic shock occurs or early in the course of endotoxic shock to elicit a beneficial response. Unfortunately this is not usually possible in the clinical situation. Further, the possibility of eliciting a detrimental response by use of drugs at inappropriate dosages or too late in the course of the disease must be considered. In time, therapies may be grouped into those that hold promise for being beneficial in the patient at risk for endotoxic shock and those that are beneficial...Continue Reading

References

Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M W RadomskiS Moncada
Dec 1, 1991·European Journal of Clinical Investigation·A Billiau, F Vandekerckhove
Oct 1, 1991·European Journal of Immunology·C Y WuG Delespesse
Oct 1, 1989·The American Review of Respiratory Disease·H HaradaT A Raffin
Aug 1, 1988·The American Review of Respiratory Disease·A IshizakaT A Raffin
Jun 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·I C KettelhutA L Goldberg
Mar 1, 1988·European Journal of Pharmacology·E D HallJ M McCall
May 29, 1986·Biochemical and Biophysical Research Communications·S L KunkelJ Larrick
Oct 24, 1986·Science·K J TraceyJ D Albert
Jun 1, 1995·Annals of Medicine·I Pörsti, I Paakkari
Nov 1, 1994·International Journal of Microcirculation, Clinical and Experimental·R F PotterA C Groom
May 1, 1995·Journal of Vascular Research·G J Dusting
Jan 1, 1995·Scandinavian Journal of Gastroenterology. Supplement·D M McCarthy
Dec 1, 1994·Journal of Critical Care·D JohnsonI Mayers
Jun 1, 1994·Antimicrobial Agents and Chemotherapy·J M PrinsP Speelman
Jan 1, 1994·Acta Anaesthesiologica Scandinavica·G H Sigurdsson, H Youssef
Jan 1, 1993·Intensive Care Medicine·G H SigurdssonA Banic
Feb 1, 1993·Current Opinion in Immunology·N J Goulding, P M Guyre
Mar 1, 1993·Diagnostic Microbiology and Infectious Disease·R H EngT Ogbara
Oct 1, 1995·The Histochemical Journal·B J Whittle
Jun 1, 1996·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·M Degré

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Citations

Dec 21, 2005·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Fausto LabrutoJarle Vaage
Nov 25, 2000·Journal of Hematotherapy & Stem Cell Research·P M WongS W Chung
Feb 13, 2001·Infection and Immunity·K VisvanathanJ B Zabriskie
Jun 7, 2021·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Guilherme T VossEthel A Wilhelm

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