Treatment of eosinophilic esophagitis: overview, current limitations, and future direction

The American Journal of Gastroenterology
Matthew Bohm, Joel E Richter

Abstract

Eosinophilic esophagitis (EE) is an increasingly recognized syndrome presenting with upper gastrointestinal (UGI) symptoms in association with hypereosinophilia (>15 eosinophils/HPF) on esophageal mucosal biopsies. The pathogenesis is unknown, but the candidate etiologies include food and aeroallergen hypersensitivity and an unusual presentation of gastroesophageal reflux disease. This review will highlight the treatments of EE in children and adults. Current treatments are controversial, few data are available in adults, and long-term studies are almost nonexistent. We outline the limitations in the current studies and suggest seven major issues in the study design that must be addressed in future drug trials.

References

Apr 29, 1998·Journal of Pediatric Gastroenterology and Nutrition·C A LiacourasE Ruchelli
Jul 21, 1998·Journal of Pediatric Gastroenterology and Nutrition·W A FaubionD K Freese
Jan 3, 2001·The Journal of Clinical Investigation·A MishraM E Rothenberg
Apr 24, 2001·The American Journal of Gastroenterology·J B MorrowJ E Richter
Dec 14, 2001·The Journal of Allergy and Clinical Immunology·M E RothenbergP E Putnam
Feb 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anil MishraMarc E Rothenberg
Jan 9, 2003·Gastrointestinal Endoscopy·Victor L FoxGlenn T Furuta
May 10, 2003·The American Journal of Gastroenterology·Jonathan E MarkowitzChris A Liacouras
Jul 4, 2003·Mayo Clinic Proceedings·Amindra S AroraThomas C Smyrk
Oct 2, 2003·Gastrointestinal Endoscopy·John CroeseNeal I Walker
Oct 18, 2003·The Journal of Allergy and Clinical Immunology·Matthew I FoggJonathan M Spergel
Dec 23, 2003·The American Journal of Gastroenterology·N A TobeyR C Orlando
Jan 10, 2004·The Journal of Allergy and Clinical Immunology·Marc E Rothenberg
Mar 5, 2004·Gastrointestinal Endoscopy·Jon W PotterWalter J Hogan
Jun 30, 2004·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Richard J NoelMarc E Rothenberg
Mar 1, 2005·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·P CantùR Penagini
Mar 15, 2005·Gastroenterology·William J Barlow, Roy C Orlando
Jun 4, 2005·Gastrointestinal Endoscopy·Tusar K DesaiGlenn T Furuta
Jun 29, 2005·Radiology·Stefan L ZimmermanDavid A Katzka
Nov 1, 2005·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jeremy R ParfittDavid K Driman
Nov 11, 2005·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Jonathan M SpergelChris A Liacouras
Dec 20, 2005·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Chris A LiacourasJonathan E Markowitz
Jun 1, 2006·Journal of Veterinary Internal Medicine·Clare RusbridgeBermans J Iskandar
Jul 25, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Amir F KagalwallaB U K Li
Dec 13, 2006·The Journal of Allergy and Clinical Immunology·Miguel L SteinMarc E Rothenberg
May 29, 2007·The American Journal of Gastroenterology·Stuart Jon SpechlerRhonda F Souza
Jun 22, 2007·The American Journal of Gastroenterology·Seema S AcevesRanjan Dohil
Aug 9, 2007·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Matthew S CohenSidney Cohen
Oct 9, 2007·Gastroenterology·Glenn T FurutaUNKNOWN First International Gastrointestinal Eosinophil Research Symposium (FIGERS) Subcommittees
Feb 2, 2008·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Elizabeth T SchaeferSandeep K Gupta
Feb 22, 2008·The American Journal of Gastroenterology·Sonali RodrigoParakrama Chandrasoma

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Citations

Aug 29, 2009·Digestive Diseases and Sciences·Ramalinga R KedikaStuart Jon Spechler
Mar 20, 2010·Digestive Diseases and Sciences·John William Jacobs, Stuart Jon Spechler
Feb 15, 2011·Therapeutic Advances in Gastroenterology·Jonathan RickerKevin Franklin
Jan 17, 2013·World Journal of Gastroenterology : WJG·Michaela MüllerTill Wehrmann
Jun 26, 2009·Digestive Diseases and Sciences·Fouad J MoawadRoy K Wong
Jul 27, 2011·Journal of Pediatric Gastroenterology and Nutrition·Daniel J MulderChristopher J Justinich
Aug 8, 2009·The American Journal of Gastroenterology·Shehzad Nawaz Merwat, Stuart Jon Spechler
Mar 6, 2015·Clinical and Translational Allergy·Isabel J SkypalaUNKNOWN Allergy-focussed Diet History Task Force of the European Academy of Allergy and Clinical Immunology
Nov 6, 2009·The American Journal of Gastroenterology·J Molina-InfanteS Porcel-Carreño
Apr 1, 2010·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·B BasseriJ L Conklin
Apr 1, 2010·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·M BohmR Thomas
Mar 6, 2019·International Journal of Immunopathology and Pharmacology·Eleonora NuceraLucio Petruzziello
Mar 20, 2010·The Cochrane Database of Systematic Reviews·Elizabeth J ElliottJonathan E Markowitz
Dec 12, 2012·Journal of Pediatric Gastroenterology and Nutrition·Dan TurnerCraig Friesen
Aug 6, 2010·Journal of Gastroenterology·Yasuhiko AbeTooru Shimosegawa
Apr 23, 2010·Scandinavian Journal of Gastroenterology·Paolo Cantù, Roberto Penagini
Feb 23, 2010·Gastrointestinal Endoscopy·Evan S DellonNicholas J Shaheen

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