Treatment of Eosinophilic Granulomatosis with Polyangiitis: A Review

Drugs
Loïc Raffray, Loïc Guillevin

Abstract

Eosinophilic granulomatosis with polyangiitis (formerly Churg-Strauss syndrome) is a rare type of anti-neutrophil cytoplasm antibody-associated vasculitis. Nevertheless, eosinophilic granulomatosis with polyangiitis stands apart because it has features of vasculitis and eosinophilic disorders that require targeted therapies somewhat different from those used for other anti-neutrophil cytoplasm antibody-associated vasculitides. Considerable advances have been made in understanding the underlying pathophysiology of eosinophilic granulomatosis with polyangiitis that have highlighted the key role of eosinophils and opened new therapeutic opportunities. Its conventional treatment relies mainly on agents that decrease inflammation: corticosteroids and immunosuppressant adjunction for severe manifestations. New therapeutic approaches are needed for refractory disease, relapses and issues associated with corticosteroid dependence, especially for asthma manifestations. Drugs under evaluation mostly target eosinophils and B cells. Results of low-evidence-based trials suggested possible efficacies of biologicals: B-cell-blocking rituximab and anti-immunoglobulin E omalizumab. Recently, the first large-scale randomised controlled trial on ...Continue Reading

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Citations

May 31, 2019·Expert Opinion on Biological Therapy·Daniel EnnisChristian Pagnoux
Jun 26, 2020·The Australasian Journal of Dermatology·Janice YeonSamuel Zagarella
Apr 16, 2020·Expert Opinion on Biological Therapy·Loïc Raffray, Loïc Guillevin
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Dec 14, 2018·Journal of Clinical Medicine·Philipp GaucklerAndreas Kronbichler
Jul 12, 2020·La Presse médicale·Loïc Raffray, Loïc Guillevin
Jun 1, 2021·Curēus·Kathryn M Burtson, Jonathan Bishop

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