PMID: 9548222Apr 21, 1998Paper

Treatment of epilepsy following rejection of epilepsy surgery

Seizure : the Journal of the British Epilepsy Association
P Wolf

Abstract

Important progress has been made with the development of both surgical and medicinal treatment of epilepsy but these two developments are rarely seen in a common perspective. Today epilepsy surgery should be discussed with the patient when a reasonable degree of pharmacoresistance has been established, and the chances of an operation clearly outweigh its risks. At that time, there will still be a number of pharmacological options. A study of 15 patients who were evaluated for at least four years after surgery had been considered but rejected after intensive monitoring, pharmacological pursuit was successful in eight, and failed in seven. The successfully treated patients comprise three who became seizure free, and one with isolated auras as the only persisting seizure type. The successful regimens were highly individual, stretching from monotherapies to one four-drug combination. The idea of presenting this small series is not to promote or establish any therapeutic strategies and guidelines but, rather, to draw attention to a neglected interface between surgical and medicinal procedures, and to increase awareness that epilepsy therapy will still be most successful when it is seen as a whole, and must not be split up into compe...Continue Reading

References

Jul 1, 1992·Postgraduate Medical Journal·A Hopkins
Jan 1, 1986·Annals of Neurology·D Schmidt, K Richter
Dec 1, 1982·Journal of Neurology, Neurosurgery, and Psychiatry·D Schmidt
Sep 1, 1994·Seizure : the Journal of the British Epilepsy Association·R M DasheiffJ R Lave

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Citations

Oct 3, 2014·Acta Neurologica Scandinavica·O M GonenM Y Neufeld
Sep 27, 2003·European Journal of Human Genetics : EJHG·Gianna ZeiA Silvana Santachiara-Benerecetti
Apr 28, 2018·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Mike B MatthewsBen Buse
Aug 31, 2020·Seizure : the Journal of the British Epilepsy Association·Junhong MaXuefeng Wang

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