PMID: 409803Jun 1, 1977

Treatment of epilepsy with clonazepam and its effect on other anticonvulsants

Journal of Neurology, Neurosurgery, and Psychiatry
R N NandaI D Melville


Clonazepam was added to the treatment of patients with poorly controlled epilepsy in a double-blind trial and an open trial. Considerable improvement occurred with patients with myoclonic jerks and tonic-clonic convulsions, and with photosensitive epilepsy. Patients with atypical petit mal and focal epilepsies also improved. Drowsiness was initially common but lasted only a short time. No evidence was found for an action of clonazepam on the metabolism of other drugs, but treatment with phenobarbitone lowered serum concentrations of clonazepam. We conclude that clonazepam is particularly valuable in epilepsy with associated myoclonsu and in photosensitive epilepsy.


Jan 1, 1976·Neurology·M A Goldberb, J D Dorman
Sep 1, 1973·Epilepsia·T R Browne, J K Penry
Apr 1, 1973·Antimicrobial Agents and Chemotherapy·K G NaberP O Madsen
Jan 1, 1974·European Neurology·G Scollo-LavizzariN De La Cruz
Jul 6, 1974·The Medical Journal of Australia·C Y HuangW J Hensley
Feb 12, 1973·Clinica Chimica Acta; International Journal of Clinical Chemistry·J H Goudie, D Burnett


Dec 6, 2001·Current Treatment Options in Neurology·Basim M. Uthman, Andreas Reichl
Oct 27, 2001·Journal of Clinical Pharmacy and Therapeutics·Eiji YukawaY Goto
Jun 8, 2001·Paediatric Drugs·C P Panayiotopoulos
Jan 1, 1980·Annals of Neurology·S Giménez-Roldán, M Martín
Apr 4, 2008·Acta Neurologica Scandinavica·J RissS Collins
Feb 1, 1983·Acta Neurologica Scandinavica·D G Lambie, R H Johnson
May 3, 2018·The Cochrane Database of Systematic Reviews·Lin SongYuntao Jia
Jul 24, 2018·Expert Review of Neurotherapeutics·Shweta Bhat, Subramaniam Ganesh
Sep 1, 1989·Epilepsia·T Obeid, C P Panayiotopoulos
Oct 1, 1979·Epilepsia·S Giménez-Roldán, M Martín
Sep 1, 1988·The Japanese Journal of Psychiatry and Neurology·W SunaoshiH Shirai
Nov 9, 2005·Expert Review of Neurotherapeutics·Michael KoutroumanidisStella Veronica Tan
Apr 21, 2020·The Cochrane Database of Systematic Reviews·Lin SongYuntao Jia
Jan 1, 1984·Clinical EEG (electroencephalography)·E Sáenz-LopeJ Bufil
May 1, 1984·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·P S Albright, J Bruni

Related Concepts

Urgent Care
Clinical Trials
Double-Blind Method
Drug Evaluation
Drug Interactions
Single Seizure
Benign Occipital Epilepsy

Related Feeds

Absence Epilepsy

Absence epilepsy is a common seizure disorder in children which can produce chronic psychosocial sequelae. Discover the latest research on absence epilepsies here.