PMID: 16518526Mar 7, 2006Paper

Treatment of essential arterial hypertension with enalapril does not result in normalization of endothelial dysfunction of the conduit arteries

Angiology
Barbara ErzenMiso Sabovic

Abstract

It is assumed that endothelial dysfunction due to arterial hypertension could be improved or even normalized by antihypertensive treatment. The present study was designed to explore that assumption in patients with essential hypertension treated with an angiotensin-converting enzyme (ACE) inhibitor-enalapril. Twenty-eight patients (mean age: 55.1 years) who fulfilled the following criteria were included: essential arterial hypertension present for more than 2 years, monotherapy with enalapril for at least 1 year, adequate treatment (blood pressure in the last year <140/90 mm Hg) and absence of other factors (smoking, hypercholesterolemia, diabetes, obesity), which could importantly influence endothelial function. The flow-mediated (endothelium-dependent) dilation (FMD) of the brachial artery was assessed by high-resolution ultrasound and compared with that of 22 age-matched healthy normotensive controls. The patients and controls did not differ in regard to body mass index, lipids, and plasma glucose and insulin; there were no smokers. FMD of the brachial artery was significantly decreased in patients in comparison to controls (7.9% vs 13.5%, p<0.01). FMD in patients was inversely correlated with the duration of hypertension (r...Continue Reading

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Citations

Apr 23, 2011·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Eberhard SchulzThomas Münzel
Mar 6, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Nilda Espinola-ZavaletaOscar Pérez-Méndez
Dec 16, 2006·Endothelium : Journal of Endothelial Cell Research·Dimitris TousoulisChristodoulos Stefanadis
Sep 4, 2007·Pharmacology & Therapeutics·Yuliy Y Chirkov, John D Horowitz
Jan 28, 2009·Clinical Physiology and Functional Imaging·T P Pronko, V V Zinchuk
Dec 16, 2006·The Journal of Clinical Hypertension·R Preston Mason, John R Cockcroft

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