Treatment of experimental allergic neuritis with nedocromil sodium.

Journal of Neuroimmunology
P SeeldrayersD Johnson

Abstract

Peripheral nervous system mast cells degranulate early in the development of experimental allergic neuritis (EAN). This degranulation is associated with the release of vasoactive amines, chemoattractants and myelinolytic proteases which could provide a focus for inflammatory demyelination. To further assess the importance of mast cell degranulation in the development of EAN, we have treated Lewis rats inoculated with peripheral nervous system myelin and complete Freund's adjuvant, with nedocromil sodium, an anti-inflammatory drug with mast cell stabilizing properties. Treatment with nedocromil sodium (100-150 mg/kg), 3 times daily, starting on day 7 post-inoculation, significantly decreases the incidence and the severity of the disease. Histological examination of sciatic nerves confirms the absence of subclinical disease in successfully treated animals. The possible mode of action of the drug is discussed.

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Citations

Sep 1, 1992·Neurochemical Research·D Johnson, W Krenger
Oct 1, 1991·Journal of the Neurological Sciences·L BøS Mørk
Nov 1, 1994·Journal of the Neurological Sciences·S L WatsonJ D Pollard
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Sep 4, 2007·Brain Research·Mona KhalilAnn-Judith Silverman
Jul 29, 2006·Pediatric Clinics of North America·Martin J HessnerAnne E Kwitek
Sep 16, 2006·Immunological Reviews·Monika Fijak, Andreas Meinhardt
Jun 12, 2014·Diabetes·Dario A GutierrezHans-Reimer Rodewald
Mar 1, 1991·The Journal of Investigative Dermatology·R F Horan, K F Austen
Jul 27, 2014·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Elaine Zayas Marcelino da SilvaConstance Oliver
Dec 20, 2002·Nature·Christophe Benoist, Diane Mathis
Feb 1, 1995·Muscle & Nerve·H P HartungK V Toyka
Nov 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Martin J HessnerSoumitra Ghosh
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Aug 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alison L Christy, Melissa A Brown
Feb 16, 2021·Frontiers in Aging Neuroscience·Kathleen M Hagen, Shalina S Ousman
Nov 18, 2000·The Journal of Allergy and Clinical Immunology·L Bielory

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