Treatment of experimental chronic chagas disease with trifluralin

Basic & Clinical Pharmacology & Toxicology
A ZaidenbergH Buschiazzo

Abstract

We tested trifluralin against Trypanosoma cruzi in a model of chronic Chagas disease in mice. CF1 mice (n=148) were intraperitoneally infected with 10(5) trypomastigotes of T. cruzi, H510C8C3 clone. One hundred mice were partially treated with benznidazole. Mortality was 100% at day 41 in the control group (n=48). At day 90 of the chronic disease (74% survival) mice were divided into three groups and treated orally with trifluralin (50 mg/kg/day, n=26), benznidazole (50 mg/kg/day, n=25) and vehicle (peanut oil; control group, n=23) for 60 days. Electrocardiography (under pentobarbital anaesthesia, 30 mg/kg/dose), serologic immunofluorescence and microstrout were performed at the beginning and at the end of the treatment. Mice were sacrificed at day 10 after treatment; cardiac tissue was studied histopathologically and polymerase chain reaction (PCR) was performed. Spontaneous mortality was 30.43%, 3.85% and 4% in the control, trifluralin and benznidazole groups, respectively (significant survival, P=0.03). Microstrouts were negative in all three groups. Negative immunofluorescence titers were 0%, 16% (P=0.05) and 29% (P<0.02) in the control, trifluralin and benznidazole groups, respectively. The prevailing electrocardiographic ...Continue Reading

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Citations

May 9, 2007·Infection and Immunity·Kenneth V HylandDavid M Engman
Sep 24, 2008·Expert Opinion on Investigational Drugs·Charles MadyJosé Leão de Souza
May 1, 2008·Expert Opinion on Drug Discovery·Bj FennellA Bell
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Oct 28, 2016·PLoS Pathogens·Glaucia Vilar-PereiraClaudia N Paiva
May 17, 2018·Revista Da Sociedade Brasileira De Medicina Tropical·Cauê Benito ScarimChung Man Chin

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