Treatment of experimental listeriosis by CI 934, a new quinolone

The Journal of Antimicrobial Chemotherapy
H Hof

Abstract

CI 934, a new quinolone, is only marginally more active in vitro against Listeria monocytogenes and other Listeria spp. than ciprofloxacin. A bactericidal effect is seen only after several hours of incubation. However, mice infected with a virulent strain of L. monocytogenes were protected by parenteral treatment with CI 934. With a dosage of 2 x 2 mg CI 934 per day for three days almost complete remission could be achieved. These results are somewhat better than those obtained in previous experiments with other antibiotics.

Citations

Mar 1, 1995·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·E M Jones, A P MacGowan
Apr 1, 1997·Clinical Microbiology Reviews·H HofM Kretschmar

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