PMID: 9182825Jun 1, 1997Paper

Treatment of experimental subcutaneous human melanoma with a replication-restricted herpes simplex virus mutant

The Journal of Investigative Dermatology
B P RandazzoS M Brown

Abstract

Modified, non-neurovirulent herpes simplex viruses (HSV) have shown promise for the treatment of brain tumors, including intracranial melanoma. In this report, we show that HSV-1716, an HSV-1 mutant lacking both copies of the gene coding-infected cell protein 34.5 (ICP 34.5), can effectively treat experimental subcutaneous human melanoma in mice. In vitro, HSV-1716 replicated in all 26 human melanoma cell lines tested, efficiently lysing the cells. Therapeutic infection of subcutaneous human melanoma nodules with HSV-1716 led to viral replication that was restricted to tumor cells by immunohistochemistry. Moreover, HSV-1716 treatment significantly inhibited progression of preformed subcutaneous human melanoma nodules in SCID mice and caused complete regression of some tumors. This work expands the potential scope of HSV-1-based cancer therapy.

Citations

Apr 5, 2000·The Journal of Clinical Investigation·R L Martuza
Mar 22, 2002·Nature Reviews. Cancer·F McCormick
Jan 11, 2003·Cancer Gene Therapy·John Nemunaitis, Jeffrey Edelman
Mar 26, 2011·Cancer Gene Therapy·R M Eager, J Nemunaitis
Aug 3, 2004·Cancer Gene Therapy·Eugene Lin, John Nemunaitis
Dec 3, 2015·Expert Opinion on Biological Therapy·Elizabeth S AppletonAlan Melcher
Apr 11, 2006·Cancer Gene Therapy·Y Shen, J Nemunaitis
Aug 9, 2001·Annals of Medicine·O Wildner
Aug 6, 2003·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·John Nemunaitis
Oct 6, 2000·Molecular Therapy : the Journal of the American Society of Gene Therapy·E S LambrightK L Molnar-Kimber
Mar 10, 2001·Molecular Therapy : the Journal of the American Society of Gene Therapy·C G MillerN W Fraser
Apr 28, 2001·Cytokine & Growth Factor Reviews·K L NormanP W Lee
Mar 15, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Annette SorensenMarie Boyd

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