Abstract
We investigated the effects of a combination treatment involving a pulsing magnetic field (PMF) and an antitumor drug, mitomycin C (MMC), on two experimental tumors (fibrosarcoma KMT-17 and hepatocellular carcinoma KDH-8) in WKA rats, paying attention to possible potentiation of the therapeutic effect of the antitumor drug. PMF was obtained using a system generating a pulsed current in a solenoid coil. On day 7 after tumor implantation into the right thighs of rats, the region of the tumor was exposed to PMF (frequency 200 Hz, mean magnetic flux density 40 gauss) for 1 h immediately after iv injection of MMC at a dose of 1 mg/kg. Survival rates at day 90 of KMT-17 implanted rats were 0% (0/10) in the non-treated group, 34% (4/12) in the MMC-treated group, 47% (6/13) in the PMF-treated group and 77% (10/13) in the MMC/PMF combination group. The increase of life span (ILS) of KDH-8-implanted rats in the combination therapy group was significantly prolonged (%ILS 17.6%) compared with that in the MMC-treated (%ILS 3.4%) and PMF-treated (%ILS 7.6%) groups. By using cultured cells of the above two lines of tumor, the therapeutic effects of MMC and PMF were also determined from the cell colony-forming efficiency in soft agar. The colo...Continue Reading
References
Mar 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·G M HahnI Har-Kedar
Oct 1, 1977·The Journal of Clinical Investigation·A Hamburger, S E Salmon
Jan 1, 1987·Bioelectromagnetics·B K ChangJ A Gregory
Feb 15, 1986·Experientia·K TakahashiE Fukada
Jan 1, 1986·Medical & Biological Engineering & Computing·S UenoP A Oberg
Feb 24, 1984·Science·A R LiboffR Wistar
Citations
Sep 15, 2012·Cell Biochemistry and Biophysics·Zeinab ShankayiMahsa G Mansurian
Nov 14, 2001·Journal of Photochemistry and Photobiology. B, Biology·L PangH Berg
Aug 2, 2003·Bioelectrochemistry·E Laqué-RupérezM Martínez-Morillo
Jun 21, 2013·Electromagnetic Biology and Medicine·Zeinab ShankayiAkram Mahna
Dec 17, 2009·Electromagnetic Biology and Medicine·Edward Elson
Nov 5, 2013·The Journal of Membrane Biology·A MahnaZ Shankayi
Apr 12, 2011·Bioelectromagnetics·Daguang ZhangKeiji Sato
Dec 5, 2000·Bioelectromagnetics·J R GrayJ D Parker
Aug 17, 2010·Cancer Biotherapy & Radiopharmaceuticals·Wen-Fang ChenJian-Qiang Liu
Apr 25, 2003·International Journal of Cancer. Journal International Du Cancer·Masaya KawadaTakashi Yoshiki
Feb 1, 2000·Bioelectromagnetics·N MiyagiH Iwata
Oct 24, 2002·Bioelectromagnetics·M J Ruiz-GómezM Martínez-Morillo
Jun 6, 2017·Cellular and Molecular Bioengineering·K MaryczR Pązik
Jul 1, 1994·Reviews on Environmental Health·J R SalvatoreS Mehta
Feb 1, 2000·Bioelectromagnetics·R de SezeB Veyret
Mar 7, 2020·Biophysical Journal·Christopher P AshdownMark M Fuster
Apr 16, 2021·Free Radical Biology & Medicine·Mojdeh BaratiAlireza Madjid Ansari
Aug 17, 2021·Electromagnetic Biology and Medicine·Valerii E OrelSergiy G Gychka