PMID: 2119417Sep 1, 1990Paper

Treatment of familial hypercholesterolaemia: a controlled trial of the effects of pravastatin or cholestyramine therapy on lipoprotein and apolipoprotein levels

Journal of Internal Medicine
O WiklundG Bondjers

Abstract

The efficacy and safety of a new, selective inhibitor of cholesterol synthesis, pravastatin, and the bile acid-binding resin, cholestyramine, were compared in a randomized, double-blind study of 120 patients with familial hypercholesterolaemia. After a run-in period of 8-10 weeks with assessment of dietary habits, the patients were treated with pravastatin + placebo, placebo + cholestyramine, or placebo alone. Active pravastatin therapy was initiated with 10 mg b.i.d. for 6 weeks, and was increased to 20 mg b.i.d. for the following 6 weeks. Cholestyramine was given at 24 g d-1, or the highest tolerable dose. After 6 weeks of therapy, serum total and LDL cholesterol levels were reduced by 17% and 21%, respectively, on pravastatin treatment, whereas the corresponding reductions with cholestyramine treatment were 24% and 30%, respectively. With an increased dose of pravastatin, serum and LDL cholesterol concentrations were reduced by 23% and 28%, respectively, after 12 weeks; the effect of cholestyramine was unchanged. HDL cholesterol levels increased in response to pravastatin, by 7% and 9% after 6 and 12 weeks, respectively. Concomitant changes in the concentrations of apolipoproteins B and AI were observed. Three patients disco...Continue Reading

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Citations

Jan 1, 1993·European Journal of Clinical Pharmacology·E LeitersdorfE N Muratti
Sep 1, 1990·Journal of Internal Medicine·S M Grundy
Sep 1, 1992·Current Problems in Cardiology·J S Prihoda, D R Illingworth
Nov 25, 2004·International Journal of Cardiology·Jaffar Ali RazaAssad Movahed
Mar 15, 2005·International Journal of Toxicology·Judith K MarquisMichael Jones
Jan 1, 1992·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·I WendelhagJ Wikstrand
Jun 6, 2015·Circulation. Cardiovascular Genetics·Stephanie RossGuillaume Paré
Feb 1, 1992·The Annals of Pharmacotherapy·C S Wallace, B A Mueller
Jun 14, 2021·The Lancet Child & Adolescent Health·M Doortje ReijmanAlbert Wiegman

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