Abstract
Frey's syndrome is a frequent sequela of parotidectomy, causing facial sweating and flushing because of gustatory stimuli. Although botulinum toxin type A has become first-line therapy for Frey's syndrome, some patients become resistant. In this study, we investigated whether another serotype, botulinum toxin type B, might be an effective alternative. Case series with planned data collection. Otolaryngology department in a university hospital. Seven patients aged 30 to 68 years, with severe Frey's syndrome, underwent the Minor test and had 80 U of botulinum toxin type B per cm(2) (mean total dose, 2354 U) injected intracutaneously in the mapped area of gustatory sweating. All patients were followed up for 12 months. One month after treatment, six of the seven patients reported that gustatory sweating and flushing had resolved, and, in the remaining patient, these symptoms had decreased. The Minor test confirmed a significant improvement. The subjective benefits remained stable for six months in four patients and for nine months in the remaining three patients; 12 months after treatment, all patients still reported some improvement. Botulinum toxin type B afforded symptomatic relief in a small sample of patients with Frey's synd...Continue Reading
References
May 1, 1995·Acta Oto-laryngologica·C Drobik, R Laskawi
Mar 23, 1995·The New England Journal of Medicine·S Cohen, H P Parkman
Dec 1, 1994·The Laryngoscope·H LaccourreyeD Brasnu
Jan 1, 1996·Neurology·G BorodicE Schantz
Apr 6, 1999·Archives of Otolaryngology--head & Neck Surgery·O LaccourreyeB Bonan
Jun 15, 1999·Journal of Neurology·K R KesslerR Benecke
Sep 28, 1999·The Laryngoscope·P DulguerovC Gysin
Oct 24, 2000·Cancer·J J von LindernR H Reich
Mar 29, 2001·Mund-, Kiefer- und Gesichtschirurgie : MKG·A BremerichM Schaus
Feb 20, 2002·The British Journal of Surgery·A J F Beerens, G B Snow
Aug 2, 2002·The Laryngoscope·Orlando Guntinas-Lichius
Apr 3, 2003·The Laryngoscope·Orlando Guntinas-Lichius
Jul 29, 2003·Head & Neck·André Eckardt, Christian Kuettner
Mar 10, 2004·Oral Oncology·Kuauhyama Luna-OrtizAdalberto Mosqueda-Taylor
Apr 6, 2004·Facial Plastic Surgery Clinics of North America·Orlando Guntinas-Lichius
May 26, 2004·Clinics in Dermatology·Oliver P Kreyden, E Paul Scheidegger
Sep 15, 2005·Neurology·R TintnerJ Jankovic
Jun 21, 2006·Neurotoxicity Research·D Dressler, R Eleopra
Jun 21, 2006·Neurotoxicity Research·D A Glaser
Mar 18, 2009·Archives of Otolaryngology--head & Neck Surgery·Remco de BreeC René Leemans
Citations
May 29, 2012·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·C HospH Hamm
Aug 11, 2012·Journal of Neurology·Dirk Dressler
Oct 25, 2011·The Journal of Laryngology and Otology·A SteffenB Wollenberg
Mar 12, 2013·JRSM Short Reports·Ricardo PersaudKalpesh Patel
Aug 19, 2011·Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology·Yu-Jin OhMin-Kyung Shin
Jul 28, 2015·Toxins·Niv MorAndrew Blitzer
Jan 28, 2014·International Journal of Oral and Maxillofacial Surgery·Rohit Sharma
Jul 11, 2013·Revue de stomatologie, de chirurgie maxillo-faciale et de chirurgie orale·D BatifolS Lorenzo
Feb 22, 2011·Journal of Cosmetic Dermatology·Amir FeilyHossein Kalantar
Jun 10, 2015·La Presse médicale·Nicolas Kluger, Marie-Hélène Jegou
Jul 13, 2017·Expert Opinion on Drug Safety·Christine Hosp, Henning Hamm
Mar 18, 2015·The Cochrane Database of Systematic Reviews·Chunjie LiLongjiang Li
Jan 18, 2020·Toxins·Shivam Om Mittal, Bahman Jabbari