Treatment of gastric mucosa-associated lymphoid tissue lymphoma: Helicobacter pylori eradication and beyond

Expert Review of Anticancer Therapy
Carlos Montalban, Francesca Norman

Abstract

Gastric mucosa-associated lymphoid tissue (MALT) lymphoma is the paradigm of lymphomas developing in extranodal areas after antigen stimulation. In the stomach, Helicobacter pylori colonization induces the appearance of MALT and, eventually, MALT-derived lymphoma. This type of lymphoma is initially a localized form of disease, but may disseminate and transform into high-grade lymphoma, making full staging (as for nodal lymphomas) and endoscopic ultrasonography to evaluate the penetration of the lymphoma through the gastric wall mandatory. In localized gastric MALT lymphoma, the first step in treatment is eradication of H. pylori, which results in 60-90% regression. This response is maintained for years in most patients, with only 10-15% relapse, frequently precipitated by H. pylori reinfection. A component of high-grade lymphoma, penetration to gastric serosa or beyond and translocation t(11;18) are the main factors that make lymphoma resistant to eradication. Surgery or radiotherapy can cure localized lymphomas in 75-90% of patients. Chemotherapy with alkylating agents, combination chemotherapy and purine analogs, and anti-CD20 antibodies can also induce remission of localized lymphomas refractory to eradication, as well as lo...Continue Reading

References

Nov 1, 1991·Gastroenterology·S B CogliattiK Lennert
Oct 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P HammelJ C Delchier
Apr 1, 1995·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C MontalbánJ Menarguez
May 5, 1994·The New England Journal of Medicine·J ParsonnetG D Friedman
Jan 1, 1994·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A Z RohatinerT A Lister
Sep 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J FinkeG Dölken
Aug 1, 1996·British Journal of Haematology·M LuppiG Torelli
Jan 1, 1997·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C MontalbanC Bellas
Jan 1, 1997·Annals of Oncology : Official Journal of the European Society for Medical Oncology·W S XuG Srivastava
May 20, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·N R SchechterJ Yahalom
Dec 16, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C ThiedeA Neubauer
Apr 8, 1999·Leukemia & Lymphoma·C MontalbànC Rivas
Jul 27, 1999·Annals of Internal Medicine·G SteinbachF F Cabanillas
Aug 12, 1999·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P G Isaacson
Nov 30, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·N L HarrisC D Bloomfield
Jan 22, 2000·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E M IbrahimS N Bazarbashi
Mar 17, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C ThiedeUNKNOWN German MALT Lymphoma Study Group
Apr 3, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A MorgnerE Bayerdörffer
Sep 18, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P KochUNKNOWN German Multicenter Study Group
Sep 18, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P KochUNKNOWN German Multicenter Study Group
Nov 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·L T ChenA L Cheng
Aug 15, 2002·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M RadererC C Zielinski
Aug 15, 2002·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A UllrichM Blettner
Sep 14, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gerald JägerMarkus Raderer
Nov 15, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Richard W TsangBruce J Patterson
Nov 25, 2003·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M BinnJ-C Delchier

❮ Previous
Next ❯

Citations

Sep 21, 2002·Lancet·Wolfgang FischbachHans Konrad Müller-Hermelink
Feb 15, 2011·Pathology Research International·Scott R Owens, Lauren B Smith
Mar 25, 2014·World Journal of Gastroenterology : WJG·Jeong Bae Park, Ja Seol Koo
Apr 30, 2014·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Hamed Said HabibBasem Salama El-Deek
Apr 5, 2014·Journal of Gastrointestinal Cancer·Sami SamiullahWeizheng Wang
May 9, 2008·Expert Opinion on Drug Safety·Avelyn KwokRupert Wl Leong
Oct 11, 2007·Helicobacter·Steven F Moss, Peter Malfertheiner
Sep 17, 2011·Alimentary Pharmacology & Therapeutics·J P Gisbert, X Calvet
Aug 4, 2015·The Annals of Thoracic Surgery·Kiyoshi SatohTakahiro Katsumata
Jan 15, 2015·Human Pathology·Nicole C PanarelliRhonda K Yantiss
Jul 5, 2007·The American Journal of Gastroenterology·William D CheyUNKNOWN Practice Parameters Committee of the American College of Gastroenterology
Aug 1, 2007·Personalized Medicine·Takahisa FurutaTakashi Ishizaki

❮ Previous
Next ❯

Related Concepts

Related Feeds

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.