Treatment of Genital Psoriasis: A Systematic Review

Dermatology and Therapy
Kristen M BeckWilson Liao

Abstract

Genital psoriasis affects approximately 63% of psoriasis patients at least once in their lifetime. More than any other area on the body, genital lesions significantly impair patients' psychologic well-being and quality of life. We aimed to systematically review the published evidence on the safety, efficacy, and tolerability of treatments of genital psoriasis and synthesize the available clinical data. A total of 1 randomized controlled trial, 11 open-label studies, and 26 case reports were included in our analysis, representing a total of 458 patients, of which 332 were adults and 126 were children. Topical corticosteroids were commonly used first-line for genital psoriasis and were well tolerated. Nonsteroidal agents, such as topical calcineurin inhibitors or vitamin D analogs, were also efficacious, but were often irritating. One systemic agent, ixekizumab, demonstrated efficacy in reducing genital psoriasis symptoms in a large, randomized, placebo-controlled trial. Various systemic and topical medications may improve genital psoriasis lesions, but there is a lack of high-quality evidence to guide clinical decision-making. Specific reporting of efficacy for genital psoriasis in larger controlled studies of psoriasis treatmen...Continue Reading

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Citations

May 19, 2019·The Journal of Dermatological Treatment·Kelly A ReynoldsJashin J Wu
Jul 18, 2019·American Journal of Clinical Dermatology·Aine Kelly, Caitriona Ryan
Jan 11, 2020·Journal of the European Academy of Dermatology and Venereology : JEADV·J F MerolaE Riedl
Feb 13, 2021·Frontiers in Cellular and Infection Microbiology·Shree Harsha Vijaya ChandraJohn E Common

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