Treatment of Glioblastoma in Older Adults

Current Oncology Reports
Kelly Braun, Manmeet S Ahluwalia

Abstract

Glioblastoma is the most common primary malignant brain tumor diagnosed in the USA and is associated with a poor prognosis. The outcomes in elderly patients (more than 65 years of age) are worse when compared to those younger than age 65 at the time of diagnosis. Older patients are not always offered treatments that would otherwise be considered standard of care due to comorbidities and concerns about toxicity and tolerability. The initial European Organization for Research and Treatment of Cancer study that led to approval of temozolomide in glioblastoma excluded patients more than 70 years of age. This review outlines challenges that arise in the treatment of glioblastoma in the elderly population and discusses results of recent studies that established the role of adjuvant chemotherapy in addition to radiation and surgery. There is evidence that these patients can benefit from a more aggressive and safe resection, from hypofractionated radiation treatments, and from adjuvant temozolomide.

References

Jul 1, 1994·International Journal of Radiation Oncology, Biology, Physics·G S BaumanJ G Cairncross
Mar 31, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W RoaP Forsyth
Apr 2, 2004·Nature Reviews. Cancer·Stanton L Gerson
Mar 11, 2005·The New England Journal of Medicine·Roger StuppUNKNOWN National Cancer Institute of Canada Clinical Trials Group
Mar 11, 2005·The New England Journal of Medicine·Monika E HegiRoger Stupp
Apr 13, 2007·The New England Journal of Medicine·Florence Keime-GuibertUNKNOWN Association of French-Speaking Neuro-Oncologists
Oct 30, 2007·Neurologic Clinics·Jan DrappatzPatrick Y Wen
Dec 25, 2008·Annals of Neurology·Fabio M IwamotoLauren E Abrey
Dec 31, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Teri N KreislHoward A Fine
Dec 10, 2009·Nature Reviews. Neurology·Michael WellerMonika E Hegi
Aug 11, 2010·Annals of Surgical Oncology·Kaisorn L ChaichanaAlfredo Quiñones-Hinojosa
Dec 8, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Albert LaiTimothy Cloughesy
Jan 27, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A G PallisUNKNOWN European Organisation for Research and Treatment of Cancer Elderly Task Force
May 3, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·James J VredenburghHenry S Friedman
Jun 29, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jaime Gállego Pérez-LarrayaJean-Yves Delattre
Dec 6, 2011·International Journal of Cancer. Journal International Du Cancer·Guido ReifenbergerUNKNOWN German Glioma Network
Jan 25, 2012·Journal of Neuro-oncology·Fonnet E BleekerSieger Leenstra
May 15, 2012·The Lancet Oncology·Wolfgang WickUNKNOWN NOA-08 Study Group of Neuro-oncology Working Group (NOA) of German Cancer Society
Jun 23, 2012·Cancer Treatment Reviews·Normand LaperriereMartin J van den Bent
Apr 9, 2013·Journal of Neuro-oncology·Matteo SantoniStefano Cascinu
Apr 19, 2013·Neuro-oncology·Benedikt WiestlerUNKNOWN Neuro-oncology Working Group (NOA) of the German Cancer Society
Nov 12, 2013·Journal of Neurosurgery·Abraham NoorbakhshClark C Chen
Jan 5, 2014·Chinese Journal of Cancer·Andreas F HottingerKrisztian Homicsko
Feb 12, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nicholas F MarkoRaymond E Sawaya
Feb 21, 2014·The New England Journal of Medicine·Mark R GilbertMinesh P Mehta
Feb 21, 2014·The New England Journal of Medicine·Olivier L ChinotTimothy Cloughesy
May 6, 2014·Neuro-oncology·Luc BauchetLuc Taillandier
Sep 23, 2014·The Cochrane Database of Systematic Reviews·Mustafa KhasrawNick Pavlakis
Apr 7, 2015·International Journal of Radiation Oncology, Biology, Physics·Nils D ArvoldBrian M Alexander
Jun 11, 2015·The New England Journal of Medicine·Jeanette E Eckel-PassowRobert B Jenkins
Sep 24, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Wilson RoaElena Fidarova
Dec 1, 2015·Cancer·Justin T JordanScott R Plotkin
Jan 15, 2016·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Yang YuanMao Qing
Mar 16, 2017·The New England Journal of Medicine·James R PerryUNKNOWN Trial Investigators
Jun 1, 2016·Neuro-oncology Practice·Matthew MasonJames R Perry

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Citations

Jan 19, 2019·Future Oncology·Veronica VillaniAndrea Pace
Jul 1, 2020·International Journal of Molecular Sciences·Gabriel Nery de Albuquerque RegoLionel Fernel Gamarra
Sep 16, 2020·Journal of Cancer Research and Clinical Oncology·Geon AnYong- Kil Hong
Mar 12, 2020·Journal of Neuro-oncology·Lina Marenco-HillembrandKaisorn L Chaichana
Oct 14, 2020·Cell Biology International·S Daisy PrecillaAnitha Thirugnanasambandhar Sivasubramanian
Jan 18, 2021·Clinical Neurology and Neurosurgery·Victor Lopez-RiveraYoshua Esquenazi
Apr 22, 2021·Medicine·You-Heng PengYuekang Zhang
Aug 11, 2021·Cancer Cell International·Qian LuHongming Pan
Aug 20, 2021·Frontiers in Oncology·Junshuang ZhaoZhitao Jing
Oct 12, 2021·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Danielle L WeilerJason R Powell

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