PMID: 9531395Apr 8, 1998Paper

Treatment of growth arrest by transfer of cultured chondrocytes into physeal defects

Journal of Pediatric Orthopedics
E H LeeK Bose

Abstract

Chondrocytes were cultured from cartilage harvested from the iliac apophysis and knee joints of New Zealand White (NZW) rabbits. An experimental model for growth arrest was created by excising the medial half of the proximal growth plate of the tibia of 6-week-old NZW rabbits. The cultured chondrocytes were embedded in agarose and transferred into the growth-plate defect after excision of the physis. Transfer also was performed after excision of the bony bridge in established growth arrest. In both cases, growth arrest with angular deformation of the tibia was prevented. Histologic studies confirmed the viability of the chondrocytes in the new host physis.

References

Nov 1, 1990·Journal of Pediatric Orthopedics·R V Williamson, L T Staheli
Jul 1, 1990·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·B K FosterO W Wiebkin
Jan 1, 1981·Journal of Pediatric Orthopedics·A Langenskiöld
May 1, 1993·Journal of Pediatric Orthopedics·E H LeeK Bose

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Citations

Nov 9, 2000·Biomaterials·D W Hutmacher
Jul 30, 2002·Acta Orthopaedica Scandinavica·Masatoshi TobitaTetsuhisa Motomura
Nov 11, 2011·Journal of Tissue Engineering and Regenerative Medicine·Daoyun ChenBingfang Zeng
Aug 24, 2017·Tissue Engineering. Part B, Reviews·Nichole ShawKarin A Payne
Mar 21, 2008·The American Journal of Sports Medicine·John R BabbJames H Beaty
Aug 8, 2006·Tissue Engineering·Zhen LinMing-Hao Zheng
Jun 27, 2006·The Journal of Bone and Joint Surgery. British Volume·E H Lee, J H P Hui

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