PMID: 3770055Aug 1, 1986Paper

Treatment of hairy-cell leukemia with recombinant alpha 2-interferon

European Journal of Cancer & Clinical Oncology
Z N BernemanC Huber

Abstract

Eleven patients with hairy-cell leukemia (eight with progressive and three with non-progressive disease) were treated with low dose recombinant human alpha 2-interferon. After a 3-month treatment period, nine patients showed an improvement and one patient a partial remission. By then, transfusions were not required any more and serious infections were no longer encountered. Four patients were further treated: three for a total period of 9 months and one for 6 months; all of them reached a partial or complete remission. The treatment was equally effective in patients with both progressive and non-progressive disease. Previous absence of response to splenectomy did not preclude a positive effect of IFN therapy. In two patients, IFN dose reduction was necessary due to unremitting flu-like symptoms.

References

Aug 1, 1985·British Journal of Haematology·C P WormanJ C Cawley
Jul 1, 1985·Journal of the Indian Medical Association·S N ChughM S Yadav
Jan 5, 1984·The New England Journal of Medicine·J R QuesadaJ U Gutterman

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Citations

Jan 1, 1987·Pharmacology & Therapeutics·V Bocci
Apr 13, 2001·Leukemia Research·J Andrey, A Saven
Apr 3, 2003·Best Practice & Research. Clinical Haematology·Anaadriana ZakarijaMartin S Tallman
Sep 1, 1986·Immunobiology·J R Quesada
Dec 29, 2000·Fundamental & Clinical Pharmacology·V M Lauta
Mar 24, 1999·Acta Paediatrica. Supplement·F M Ruggeri, S Declich

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