PMID: 13746Oct 1, 1976

Treatment of hemorrhagic gastritis by antacid

Annals of Surgery
S Simonian, L E Curtis


A simple and safe method of nonsurgical treatment for the control of massive acute gastric mucosal hemorrhage is described. The procedure was developed from experimental and clinical observations that the presence of gastric hydrocloric acid played an important part in the development and perpetuation of the entity. The treatment consists of complete neutralization of gastric acid with antacid to a pH of 7. The antacid is intermittently added and aspirate at 7. In a retrospective analysis, the hemorrhage was controlled in 44 of 49 patients (89%). Five patients who continued to bleed underwent surgery (10%). Three patients had vagotomy and pyloroplasty and their bleeding ceased without recurrence. Two patients underwent partial gastrectomy, but they developed recurrent bleeding and died. One patient whose bleeding has been controlled by vagotomy and pyloroplasty died without hemorrhage 10 days after operation. Of the 44 patients whose bleeding had been controlled by antacid, 11 patients died without hemorrhage one or more weeks later. These results of 89% control of hemorrhage compare favorably with those in the literature.


Feb 3, 1975·JAMA : the Journal of the American Medical Association·R M DwyerJ Cherlow
Feb 1, 1972·American Journal of Surgery·H H LeVeenR B Belfasky
Oct 1, 1972·The American Journal of Roentgenology, Radium Therapy, and Nuclear Medicine·J RöschR Antonovic
Mar 14, 1974·The New England Journal of Medicine·C A AthanasoulisT J Vander Salm
Nov 25, 1974·JAMA : the Journal of the American Medical Association·J P Papp
Dec 23, 1974·JAMA : the Journal of the American Medical Association·H O Douglass
Nov 1, 1974·Gastrointestinal Endoscopy·R T Keller, G M Logan
Dec 1, 1967·Proceedings of the Society for Experimental Biology and Medicine·H W Davenport
Feb 1, 1969·Journal of Neurosurgery·C C Watts, K Clark
Apr 1, 1964·Annals of Surgery·R C SULLIVANW R WADDELL


Mar 1, 1981·World Journal of Surgery·H J Priebe, J J Skillman
Jan 1, 1982·The Japanese Journal of Surgery·M SanoM Fujiwara
Jan 1, 1978·American Journal of Surgery·R J StraussL Wise
Mar 1, 1979·Intensive Care Medicine·J R Croker
Mar 1, 1978·The Journal of Surgical Research·B A LevineB A Pruitt
Oct 1, 1983·Journal of Pediatric Surgery·R UdassinM D Goldberg
Jan 1, 1985·Scandinavian Journal of Gastroenterology. Supplement·A FalkA Törnqvist
Aug 1, 1985·Anaesthesia and Intensive Care·K Hillman
Jun 1, 1988·Drug Intelligence & Clinical Pharmacy·R L KleimanK S Ephgrave
Dec 14, 1977·Langenbecks Archiv für Chirurgie·V SchumpelickH W Schreiber

Related Concepts

Gastric Acidity Determination
Gastric Juice
Hydrogen-Ion Concentration
Intubation, Nasogastric

Related Feeds

Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.