Treatment of hepatitis B virus-associated glomerulonephritis: a meta-analysis.

World Journal of Gastroenterology : WJG
Yu ZhangFeng-Yu Wang

Abstract

To evaluate the efficacy of antiviral or corticosteroid treatment on hepatitis B virus-associated glomerulonephritis (HBV-GN). Six and five trials were used respectively to evaluate the efficacy of either antiviral or corticosteroid treatment on HBV-GN. Pediatric patients were pooled separately to assess their response to the above treatment modalities. The primary and secondary outcomes were remission of proteinuria and clearance of Hepatitis B e-antigen (HBeAg), respectively. A fixed or random effect model was established to collect the data. The remission rate of proteinuria (RR = 1.69, 95% CI: 1.08-2.65) and the clearance rate of HBeAg (RR = 6.44, 95% CI: 3.11-13.35) were significantly higher in antiviral treatment group than in control group. The proteinuria remission was significantly associated with HBeAg clearance (P = 0.002). However, the difference in proteinuria remission rate was not statistically significant between corticosteroid treatment group and control group (RR = 1.45, 95% CI: 0.68-3.11). Antiviral therapy could significantly promote the HBeAg clearance in pediatric patients, but neither antiviral nor corticosteroid therapy could significantly decrease proteinuria in pediatric patients compared to controls. ...Continue Reading

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Citations

Mar 1, 2012·World Journal of Gastroenterology : WJG·Xiao-Yong ZhengXiao-Dong Zheng
Apr 14, 2015·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Ting LiuLiangzhong Sun
Jun 21, 2013·Kidney International·Chrysoula L PipiliEvangelos C Cholongitas
Mar 16, 2011·European Journal of Internal Medicine·Gaosi Xu, Tianlun Huang
Apr 21, 2016·Indian Journal of Pediatrics·Rohan Malik, Winita Hardikar
Aug 29, 2019·Expert Review of Clinical Pharmacology·Fabrizio FabriziEzequiel Ridruejo
Oct 5, 2017·Journal of Medical Virology·Tao PengXiangdong Yang

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