Treatment of hepatitis C in patients with haemophilia - the Israeli National Hemophilia Center experience

Haemophilia : the Official Journal of the World Federation of Hemophilia
Y MaorU Martinowitz

Abstract

Treatment with pegylated interferon (Peg-IFN) and ribavirin, now the standard of care, has been shown to achieve sustained viral response (SVR) in up to 60% of patients with hepatitis C (HCV). Studies of response to this combination in HCV-infected haemophilia patients are scarce. The aim of the study was to report the results and safety of interferon/ribavirin treatment in HCV and HCV-/HIV-infected patients at the Israeli National Hemophilia Center. A retrospective observational cohort study was conducted on haemophilia patients infected with HCV or HCV/HIV. Patients received combination of Peg-IFN and ribavirin. Few were still treated with standard interferon. The primary end-point was sustained viral response (SVR). The secondary end-point was safety, with emphasis on increased bleeding episodes. Some 18/43 (42%) HCV mono-infected haemophilia patients achieved SVR. Relapse occurred in 14 (33%), while 11 patients (25%) were non-responders. SVR was achieved among 17/37 (46%) naïve patients receiving Peg-IFN and ribavirin. Among patients with genotype-1, SVR was achieved in 12/36 (33%) and 11/30 (37%) in the whole group and Peg-IFN treated naïve patients, respectively. In HCV/HIV co-infected patients only 1 patient achieved SVR...Continue Reading

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Citations

Nov 5, 2009·Clinical Medicine : Journal of the Royal College of Physicians of London·Christine A Lee
Feb 4, 2009·Haemophilia : the Official Journal of the World Federation of Hemophilia·J T DenholmJ J Sasadeusz
Jun 22, 2011·Haemophilia : the Official Journal of the World Federation of Hemophilia·D E Fransen van de PutteE P Mauser-Bunschoten
May 7, 2021·British Journal of Haematology·Cas J IsfordinkMichael Makris

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