Treatment of hepatitis C in special populations

Journal of Gastroenterology
Goki SudaNaoya Sakamoto

Abstract

Hepatitis C virus (HCV) infection is one of the primary causes of liver cirrhosis and hepatocellular carcinoma. In hemodialysis patients, the rate of HCV infection is high and is moreover associated with a poor prognosis. In liver transplantation patients with HCV infection, recurrent HCV infection is universal, and re-infected HCV causes rapid progression of liver fibrosis and graft loss. Additionally, in patients with HCV and human immunodeficiency virus (HIV) co-infection, liver fibrosis progresses rapidly. Thus, there is an acute need for prompt treatment of HCV infection in these special populations (i.e., hemodialysis, liver transplantation, HIV co-infection). However, until recently, the standard anti-HCV treatment involved the use of interferon-based therapy. In these special populations, interferon-based therapies could not achieve a high rate of sustained viral response and moreover were associated with a higher rate of adverse events. With the development of novel direct-acting antivirals (DAAs), the landscape of anti-HCV therapy for special populations has changed dramatically. Indeed, in special populations treated with interferon-free DAAs, the sustained viral response rate was above 90%, with a lower incidence an...Continue Reading

References

Dec 24, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P MathurinM O Bitker
Sep 25, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y BenhamouT Poynard
Sep 26, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M BerenguerJ Berenguer
Mar 14, 2001·The American Journal of Cardiology·J H Stein, P E McBride
Jul 20, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·C S GrahamM J Koziel
Feb 8, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kenneth E ShermanNatasa Rajicic
Mar 1, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Montserrat Garcia-RetortilloJuan Rodes
Apr 2, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Norbert BräuJay R Kostman
Jul 30, 2004·The New England Journal of Medicine·Francesca J TorrianiUNKNOWN APRICOT Study Group
Jul 30, 2004·The New England Journal of Medicine·Raymond T ChungUNKNOWN AIDS Clinical Trials Group A5071 Study Team
Dec 16, 2004·JAMA : the Journal of the American Medical Association·Fabrice CarratUNKNOWN ANRS HCO2 RIBAVIC Study Team
Apr 5, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Suzanne BergmanJeffery Glaze
Sep 26, 2006·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Anteo Di NapoliUNKNOWN Lazio Dialysis Registry
Apr 13, 2007·Journal of the American Society of Nephrology : JASN·Kamyar Kalantar-ZadehSander Greenland
Jan 5, 2008·Clinical and Experimental Nephrology·Yuko IwasaTakashi Akiba
Jan 12, 2008·World Journal of Gastroenterology : WJG·Celal AyazMehmet Faruk Geyik
Jan 12, 2008·Annual Review of Medicine·David L Thomas
Jan 25, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Craig E GordonJohn B Wong
Jun 23, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·K WattM Charlton
Jul 4, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Juan BerenguerUNKNOWN GESIDA3603/5607 Study Group
Sep 8, 2009·The American Journal of Cardiology·Chetan V HampoleSanjiv J Shah
May 25, 2010·Hemodialysis International·Seyed-Moayed AlavianMasoud Ahmadzad-Asl
Apr 1, 2011·The New England Journal of Medicine·Fred PoordadUNKNOWN SPRINT-2 Investigators
Apr 1, 2011·The New England Journal of Medicine·Bruce R BaconUNKNOWN HCV RESPOND-2 Investigators
Jul 24, 2012·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Takashi AkibaTadao Akizawa
Jul 24, 2012·JAMA : the Journal of the American Medical Association·Berkeley N LimketkaiMark S Sulkowski
Oct 30, 2012·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Fabrizio FabriziPatrice Cacoub
Nov 15, 2012·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Jérôme DumortierVincent Leroy
Nov 23, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Khayriyyah Mohd HanafiahSteven T Wiersma
Jan 31, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·W R KimB L Kasiske
Dec 25, 2012·Journal of Hepatology·Marina Berenguer, Detlef Schuppan
Feb 23, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·José A MiraUNKNOWN Grupo Andaluz para el Estudio de las Hepatitis Víricas de la Sociedad Andaluza de Enfermedades Infecciosas
Sep 24, 2013·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Johanna KnapsteinTim Zimmermann
Mar 8, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hiromitsu KumadaEric Hughes
Apr 2, 2014·Transplant International : Official Journal of the European Society for Organ Transplantation·Nobuhisa AkamatsuYoshihiko Maehara
Apr 12, 2014·The New England Journal of Medicine·Kris V KowdleyUNKNOWN ION-3 Investigators
Apr 12, 2014·The New England Journal of Medicine·Jordan J FeldBarry Bernstein
May 8, 2014·Alimentary Pharmacology & Therapeutics·J WiegandH Hinrichsen
Jul 20, 2014·JAMA : the Journal of the American Medical Association·Mark S SulkowskiUNKNOWN PHOTON-1 Investigators
Aug 3, 2014·Journal of Hepatology·Erin GowerHomie Razavi

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Citations

Feb 6, 2020·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Naoki KawagishiNaoya Sakamoto
Jul 16, 2020·Journal of Gastroenterology and Hepatology·Goki Suda, Naoya Sakamoto
Jul 21, 2020·Expert Review of Gastroenterology & Hepatology·Nicholas Hoppmann, Omar Massoud
Jan 18, 2019·Experimental and Therapeutic Medicine·Yuhong DongGuo Lei
Jun 8, 2021·World Journal of Gastroenterology : WJG·Emanuele NicastroLorenzo D'Antiga

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NCT01958281

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SOLAR
ERADICATE

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