Treatment of high fracture risk patients in routine clinical practice

Archives of Osteoporosis
Olga LesnyakNatalya Toroptsova

Abstract

A retrospective cohort study determined the high incidence of recurrent fractures in osteoporotic patients with high fracture risk during the observation. The strategy of starting treatment with more potent regimens (zoledronic acid, denosumab and/or teriparatide) seems to have the best secondary fracture prevention efficacy. This paper describes the various medical therapy regimens prescribed to osteoporotic patients with high fracture risk and the result of treatment. We carried out a retrospective cohort study in selected Osteoporosis Centers. Patients were considered to have high fracture risk in case of a history of a low-energy hip fracture or two or more vertebral or other site fractures. A total of 812 subjects (768 women and 44 men) aged 36-95 years were included. The observation period was 2285.1 patient-years. Demographic data, clinical findings, and BMD data obtained by DXA, as well as a history of fractures that had occurred during the follow-up, were included in the analysis. Overall, at baseline, there were 637 non-vertebral fractures including 104 hip fractures. A total of 590 patients had vertebral fractures; of these, 69% suffered multiple fractures. Being on treatment, 119 (14.7%) patients developed new verte...Continue Reading

References

Dec 28, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·John T SchousboeKristine E Ensrud
Sep 5, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Jacques P BrownHenry G Bone
Feb 5, 2009·JAMA : the Journal of the American Medical Association·Dana BliucJacqueline R Center
Feb 4, 2010·Nature Reviews. Rheumatology·Nicholas HarveyCyrus Cooper
Feb 18, 2010·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·K M B HuntjensS van Helden
Aug 4, 2011·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Robert D Blank, UNKNOWN FRAX(®) Position Development Conference Members
Nov 25, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Stephen GehlbachRobert Lindsay
Jul 28, 2012·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A Diez-PerezUNKNOWN IOF CSA Inadequate Responders Working Group
Apr 17, 2013·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·K AkessonUNKNOWN IOF Fracture Working Group
Jul 26, 2013·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J A KanisUNKNOWN Epidemiology and Quality of Life Working Group of IOF
Feb 19, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Suzanne N MorinWilliam D Leslie
Jun 9, 2016·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J ZhouS Zhai
Nov 2, 2016·Health Technology Assessment : HTA·Sarah DavisNeil Gittoes
Dec 13, 2017·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A SvedbomJ A Kanis
Oct 17, 2018·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J A KanisUNKNOWN Scientific Advisory Board of the European Society for Clinical and Economic Aspects of Osteoporosis (ESCEO) and the Committe
Jun 1, 2020·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J-J BodyP Geusens

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Citations

May 28, 2021·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·U StumpfP Hadji

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