Treatment of Highly Drug-Resistant Pulmonary Tuberculosis

The New England Journal of Medicine
Francesca ConradieNix-TB Trial Team

Abstract

Patients with highly drug-resistant forms of tuberculosis have limited treatment options and historically have had poor outcomes. In an open-label, single-group study in which follow-up is ongoing at three South African sites, we investigated treatment with three oral drugs - bedaquiline, pretomanid, and linezolid - that have bactericidal activity against tuberculosis and to which there is little preexisting resistance. We evaluated the safety and efficacy of the drug combination for 26 weeks in patients with extensively drug-resistant tuberculosis and patients with multidrug-resistant tuberculosis that was not responsive to treatment or for which a second-line regimen had been discontinued because of side effects. The primary end point was the incidence of an unfavorable outcome, defined as treatment failure (bacteriologic or clinical) or relapse during follow-up, which continued until 6 months after the end of treatment. Patients were classified as having a favorable outcome at 6 months if they had resolution of clinical disease, a negative culture status, and had not already been classified as having had an unfavorable outcome. Other efficacy end points and safety were also evaluated. A total of 109 patients were enrolled in...Continue Reading

References

May 27, 2005·Antimicrobial Agents and Chemotherapy·Sandeep TyagiJ Grosset
Dec 14, 2005·Neurology·Catherine L CherryJustin C McArthur
Dec 17, 2008·Antimicrobial Agents and Chemotherapy·Anna C HaagsmaDirk Bald
Jul 31, 2009·Communicative & Integrative Biology·Ujjini ManjunathaClifton E Barry
Jan 13, 2012·The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·N R GandhiN S Shah
Oct 19, 2012·The New England Journal of Medicine·Myungsun LeeClifton E Barry
Apr 30, 2013·Emerging Infectious Diseases·Max R O'DonnellC Robert Horsburgh
Sep 10, 2014·The New England Journal of Medicine·Stephen H GillespieUNKNOWN REMoxTB Consortium
Oct 23, 2014·The New England Journal of Medicine·Corinne S MerleUNKNOWN OFLOTUB/Gatifloxacin for Tuberculosis Project
Oct 23, 2014·The New England Journal of Medicine·Amina JindaniUNKNOWN RIFAQUIN Trial Team
Dec 10, 2015·The European Respiratory Journal·Alexander S PymUNKNOWN TMC207-C209 Study Group
Jul 14, 2018·The Lancet. Respiratory Medicine·Kathryn SchnippelFrancesca Conradie
Sep 15, 2018·Lancet·UNKNOWN Collaborative Group for the Meta-Analysis of Individual Patient Data in MDR-TB treatment–2017Dick Menzies
Mar 14, 2019·The New England Journal of Medicine·Andrew J NunnUNKNOWN STREAM Study Collaborators
Apr 20, 2019·Emerging Infectious Diseases·Lawrence MbuagbawChristian Lienhardt

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Citations

Mar 5, 2020·The New England Journal of Medicine·Guy Thwaites, Payam Nahid
May 28, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zhijun ZhuangZhenkun Ma
May 6, 2020·Antimicrobial Agents and Chemotherapy·Andreas H DiaconCarl M Mendel
Jun 26, 2020·Dalton Transactions : an International Journal of Inorganic Chemistry·Luiz G F LopesEduardo H S Sousa
May 10, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Navisha DookieKogieleum Naidoo
Aug 12, 2020·Antimicrobial Agents and Chemotherapy·Wael A AlghamdiCharles A Peloquin
Aug 8, 2020·Journal of Clinical Microbiology·Emily MacLeanMadhukar Pai
Sep 24, 2020·Expert Review of Respiratory Medicine·James A SeddonH Simon Schaaf
Sep 13, 2020·Current HIV/AIDS Reports·Elisa H Ignatius, Susan Swindells
Jun 2, 2020·Frontiers in Immunology·Caylin G WinchellJoAnne L Flynn
Jun 11, 2020·The New England Journal of Medicine·Mathieu S BolhuisOnno W Akkerman
Oct 6, 2020·Frontiers in Immunology·Sam AfkhamiZhou Xing
Oct 29, 2020·Journal of Family Medicine and Primary Care·Anivita AggarwalNaveet Wig
Jun 11, 2020·The New England Journal of Medicine·Francesca ConradieAngela M Crook

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Methods Mentioned

BETA
blood draws
X-ray

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