Abstract
The objective of the present prospective, noncomparative, multicenter study was assess the safety and efficacy of gentamicin and doxycycline therapy for human brucellosis. In the first part of the study, a cohort of 17 patients received 100 mg of doxycycline (or 50 mg/kg of body weight per day if the body weight was < 40 kg) orally every 12 h for 45 days (cohort 1). In the second part of the study a subsequent cohort of 35 patients was treated with doxycycline at the same dosage for 30 days (cohort 2). All patients were treated intramuscularly with gentamicin at 240 mg (or 5 mg/kg per day if the body weight was < 50 kg) once daily for the first 7 days. Both cohorts showed a favorable response during therapy, and there were no therapeutic failures. Relapse was noted in 1 (5.9%; 95% confidence interval [95% CI], 0.15 to 28.7%) of the 17 patients in cohort 1 and in 8 (22.9%; 95% CI, 10.4 to 40.1%) of the 35 patients in cohort 2. Nineteen patients (36.5%; 95% CI, 23.6 to 51.0%) had adverse effects, with no differences between cohorts, and no patients had a treatment-limiting adverse effect. The study indicates that the combination of doxycycline for 45 days and gentamicin for 7 days is an effective and well-tolerated therapy for hu...Continue Reading
References
Aug 1, 1979·Journal of Pharmaceutical Sciences·A P De Leenheer, H J Nelis
Sep 1, 1992·AIDS·J Pedro-BotetJ Rubiés-Prat
Jul 1, 1992·Annals of Internal Medicine·J ArizaM R Miravitlles
May 1, 1990·Antimicrobial Agents and Chemotherapy·J M CisnerosA Alarcón
Nov 1, 1990·Reviews of Infectious Diseases·W H Hall
May 1, 1990·Diagnostic Microbiology and Infectious Disease·S M QadriY Ueno
Jan 1, 1989·Chemotherapy·J D Colmenero CastilloA Alonso
Mar 1, 1989·The Journal of Antimicrobial Chemotherapy·G AcocellaJ Roux
Dec 1, 1985·The Journal of Infectious Diseases·J ArizaP Fernández-Viladrich
Oct 1, 1985·Antimicrobial Agents and Chemotherapy·J ArizaP Fernández-Viladrich
Apr 1, 1969·The Journal of Infectious Diseases·J A Waitz, M J Weinstein
Sep 1, 1983·Reviews of Infectious Diseases·E J Young
May 3, 1993·The Medical Journal of Australia·R Chan, R P Hardiman
May 1, 1993·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J M MontejoC Aguirre
Sep 1, 1995·Antimicrobial Agents and Chemotherapy·J SoleraM D Ruiz-Ribó
Aug 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·E J Young
Mar 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J SoleraM D Ruiz-Ribó
Feb 1, 1953·A.M.A. Archives of Internal Medicine·G B MAGILL, J H KILLOUGH
Jul 25, 1964·Lancet·W W SPINK
Citations
Apr 1, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Mohammad Reza Hasanjani RoushanAli Akbar Valayati
Oct 19, 2012·The Cochrane Database of Systematic Reviews·Reza Yousefi-NooraieParham Sadeghipour
Oct 3, 2013·Asian Pacific Journal of Tropical Medicine·Xiu-Li XuXiao-Ke Hao
Jun 18, 2014·Scandinavian Journal of Infectious Diseases·Masoomeh SofianAmitis Ramezani
Dec 10, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J SoleraL Abad
Feb 15, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J SoleraUNKNOWN Grupo de Estudio de Castilla la Mancha de Enfermedades Infecciosas Group
Feb 7, 2008·Expert Review of Anti-infective Therapy·Jaffar A Al-Tawfiq
Apr 20, 2007·Transactions of the Royal Society of Tropical Medicine and Hygiene·Gregory J JenningsFrancis J Mahoney
Feb 6, 2013·The American Journal of Tropical Medicine and Hygiene·Karina RománMayuko Saito
Jul 1, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sophie RobichaudEarl Rubin
Jan 10, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Juan D ColmeneroJosé M Reguera
Mar 11, 2005·Expert Opinion on Pharmacotherapy·Georgios PappasEpameinondas Tsianos
Mar 20, 2009·Journal of Chemotherapy·H AliskanH Arslan
Jan 10, 2006·Journal of Paediatrics and Child Health·A TrivediA Kesson
Oct 22, 2008·Critical Reviews in Biotechnology·C Ganesh KumarAnnapurna Jetty
Mar 11, 2010·The Journal of Antimicrobial Chemotherapy·M R Hasanjani RoushanA Bijani
Mar 7, 2012·PloS One·Julián Solís García del Pozo, Javier Solera
May 23, 2020·Scientific Reports·Thea S B MøllerJohn E Olsen
Dec 4, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Javier SoleraUNKNOWN Grupo de Estudio de Castilla-la Mancha de Enfermedades Infecciosas
Aug 15, 2014·International Journal of Microbiology·Rohaidah HashimK N Leong
Oct 16, 2001·Antimicrobial Agents and Chemotherapy·M Maurin, D Raoult
Nov 24, 1999·Journal of Clinical Microbiology·P MorataJ D Colmenero
Jul 1, 1997·Antimicrobial Agents and Chemotherapy·O AbramsonP Yagupsky
May 13, 1999·Mayo Clinic Proceedings·R S Edson, C L Terrell
Feb 1, 2014·The Lancet Infectious Diseases·Jesica A HerrickTara N Palmore
May 3, 2008·Pediatrics·Mark W Shen