PMID: 8944215Nov 1, 1996Paper

Treatment of hyperemesis gravidarum with the 5-HT3 antagonist ondansetron (Zofran)

Postgraduate Medical Journal
D G Tincello, M J Johnstone

Abstract

Ondansetron is a 5-hydroxytryptamine receptor antagonist which is known to be a highly effective anti-emetic drug for chemotherapy-associated nausea and vomiting and for postoperative nausea. We report here a case where ondansetron was used in severe hyperemesis gravidarum to avoid parenteral nutrition. The drug was used intermittently in every trimester with no apparent adverse effects on mother or infant.

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