Abstract
We studied the efficacy of B vitamins as a treatment for hyperhomocysteinemia and endothelial dysfunction in renal transplant recipients in the Chinese population. A total of 36 stable renal transplant recipients with hyperhomocysteinemia were randomly assigned to folate treatment (5 mg folic acid per day, 50 mg vitamin B6 per day and 1,000 microg vitamin B12 per day) or to the control group (placebo only) for 6 months. All subjects underwent tests for creatinine, creatinine clearance rate, average blood pressure, total cholesterol, triglyceride and fasting homocysteine. Endothelial function was evaluated using high resolution vascular ultrasound. Homocysteine significantly decreased in those with folate treatment after intervention compared with baseline (12.6 +/- 3.9 vs 20.1 +/- 5.4 micromol/l, t = 5.3, p <0.01), whereas no significant changes were observed in controls. In the folate treatment group endothelium dependent and independent vasodilatation responses significantly increased after intervention (12.2% +/- 4.6% vs 8.8% +/- 5.2%, t = 2.9, p <0.01 and 17.6% +/- 3.9% vs 12.2% +/- 4.7%, t = 3.4, p <0.01, respectively). However, no significant changes were observed in controls. Endothelium dependent and independent vasodil...Continue Reading
References
Nov 7, 1992·Lancet·D S CelermajerJ E Deanfield
Nov 1, 1989·Indian Journal of Pediatrics·S Fucharoen, P Winichagoon
Jun 1, 1989·Circulation·M R MalinowB Upson
Nov 1, 1984·Stroke; a Journal of Cerebral Circulation·L E BrattstromB L Hultberg
Sep 1, 1995·British Heart Journal·K E SorensenJ E Deanfield
Nov 1, 1995·Journal of the American College of Cardiology·T J AndersonA C Yeung
Jun 15, 1997·Hospital Practice·G N WelchJ Loscalzo
May 7, 1998·Archives of Internal Medicine·N J WaldJ M Scott
Aug 5, 1998·Atherosclerosis·P AmbrosiD Métras
Nov 26, 1998·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·D DuclouxJ M Chalopin
Feb 23, 1999·Kidney International·M FödingerG Sunder-Plassmann
Aug 10, 1999·Transplantation·A G BostomI H Rosenberg
Jan 5, 2000·Journal of the American Society of Nephrology : JASN·Didier DuclouxJean-Marc Chalopin
Dec 9, 2000·Transplant International : Official Journal of the European Society for Organ Transplantation·R MarcucciM Salvadori
Jan 3, 2001·Transplantation Proceedings·E ThervetH Kreis
Feb 13, 2001·Kidney International. Supplement·A G BostomJ Selhub
May 2, 2001·Transplantation·R MarcucciM Salvadori
Sep 20, 2001·Journal of the American Society of Nephrology : JASN·Allon N FriedmanIrwin H Rosenberg
Oct 29, 2002·Diabetes Care·Allon N FriedmanUNKNOWN Collaborative Study Group
Jun 7, 2003·Transplantation·Rossella MarcucciMaurizio Salvadori
Citations
Nov 23, 2012·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Li-Hua LiuYan Xiong
May 6, 2015·The Cochrane Database of Systematic Reviews·Amy KangMeg J Jardine
Jan 13, 2015·The Cochrane Database of Systematic Reviews·Amit D RavalRama Walia
Jul 1, 2014·Transplantation·Ali MonfaredMohammad Najafi Ashtiani