PMID: 3743860Aug 1, 1986Paper

Treatment of hypertension during pregnancy with hydralazine monotherapy or with combined therapy with hydralazine and pindolol

European Journal of Obstetrics, Gynecology, and Reproductive Biology
J RosenfeldE Zmora

Abstract

Forty-four consecutive patients referred for treatment because of hypertension (greater than 150/90 mmHg) occurring during pregnancy were randomly allocated to one of two treatment groups, hydralazine alone (n = 21) or hydralazine combined with pindolol (n = 23). Satisfactory blood pressure control (diastolic pressure less than 90 mmHg) was achieved in 86% of patients receiving hydralazine alone and 91% of those on combined therapy. Although the treatment did not lower the overall incidence of hypertensive complications it appeared to delay the onset of such complications until successful surgical intervention was possible. Fetal outcome was similar in both groups and there was no perinatal mortality in this high-risk population. Although blood pressure control was similar in both groups of patients, combined therapy with hydralazine and pindolol can be considered to be superior to hydralazine monotherapy, since in patients treated with the combination the incidence and intensity of troublesome side-effects was markedly lower.

References

Sep 1, 1978·British Journal of Obstetrics and Gynaecology·B A LiebermanE Belsey
Mar 1, 1974·Anesthesia and Analgesia·R L ReedF W Hehre
Jun 1, 1966·Circulation·A P Fishman
Jan 1, 1982·British Journal of Clinical Pharmacology·D DuboisP Catherine
Oct 15, 1984·American Journal of Obstetrics and Gynecology·P C RubinJ L Reid
Dec 1, 1984·Clinical Obstetrics and Gynecology·F P Zuspan
Jan 1, 1982·British Journal of Clinical Pharmacology·B J ClarkA Bertholet
Feb 1, 1980·British Journal of Obstetrics and Gynaecology·G Bott-KannerJ B Rosenfeld

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Citations

Feb 5, 2000·European Journal of Obstetrics, Gynecology, and Reproductive Biology·L A MageeG Koren
Jul 25, 1996·The New England Journal of Medicine·B M Sibai
Apr 29, 2011·BMC Public Health·Mehnaz JabeenZulfiqar A Bhutta
Apr 12, 2011·Best Practice & Research. Clinical Obstetrics & Gynaecology·Laura A MageeA Kathirgamanathan
Oct 18, 2000·The Cochrane Database of Systematic Reviews·L A Magee, L Duley
Oct 3, 2018·The Cochrane Database of Systematic Reviews·Edgardo AbalosCelina Gialdini
Dec 4, 2009·Expert Review of Cardiovascular Therapy·Jill Newstead-Angel, Paul S Gibson
Feb 8, 2014·The Cochrane Database of Systematic Reviews·Edgardo AbalosD Wilhelm Steyn
Aug 15, 2003·The Cochrane Database of Systematic Reviews·L A Magee, L Duley

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