PMID: 2485024Jan 1, 1987Paper

Treatment of hypertensive heart disease with ACE inhibitors

Journal of Cardiovascular Pharmacology
K O Stumpe

Abstract

Hypertensive left ventricular hypertrophy is associated with a variety of complications including congestive heart failure, arrhythmias, and ischemic heart disease. Unloading the system in time by antihypertensive drug treatment should prevent or reverse left ventricular hypertrophy. Although most antihypertensive agents can control blood pressure in a majority of patients, only a select subset of these pharmacologic agents will reverse left ventricular mass. There is evidence to suggest that angiotensin-converting enzyme (ACE) inhibitors can play an important role in protecting the heart during the various phases of evolution of hypertensive heart disease both acutely and on a long-term basis. Several studies in hypertensive humans and experimental animals have documented the effectiveness of ACE inhibitors in reducing cardiac hypertrophy. In hypertensive patients with left ventricular hypertrophy, the ACE inhibitor captopril 3 and 9 months after starting treatment significantly reduced left ventricular mass as well as left ventricular posterior wall and septal wall thickness. The mechanism of regression of left ventricular mass by ACE inhibition is speculative. The absence of a reflex hyperadrenergic state in the face of bloo...Continue Reading

Citations

Feb 1, 1995·Pharmacology & Therapeutics·J R CockcroftD J Webb

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