Treatment of hypertensive hyperuricemic patients with a new beta blocker-diuretic combination

The antihypertensive activity of two fixed beta-blocker combinations was compared in a randomized double-blind study. 18 patients with degree I or II hypertension and hyperuricaemia were treated with a once daily dose for 4 weeks. 9 patients received 200 mg celiprolol. HCl +25 mg chlorthalidone, and 9 patients were treated with 100 mg atenolol + 25 mg chlorthalidone. Both substances produced a similar reduction in blood pressure and heart rate. There was a significant rise in the serum uric acid level in both treatment groups.