Treatment of hyperthyroidism due to inappropriate secretion of thyrotropin with the somatostatin analog SMS 201-995

The Journal of Clinical Endocrinology and Metabolism
P Beck-PeccozA Pinchera

Abstract

The management of hyperthyroidism due to inappropriate secretion of TSH (IST) includes agents that selectively suppress TSH hypersecretion both in patients with TSH-secreting tumor [neoplastic IST (nIST)] in whom pituitary surgery was unsuccessful and in those with selective pituitary resistance to thyroid hormone action [nonneoplastic IST (nnIST)]. Among such agents, somatostatin administration has proven to be effective in blocking TSH hypersecretion, but its short plasma half-life prevented its use in long term therapeutic trials. The recent availability of a potent and long-acting analog of somatostatin (SMS 201-995, Sandostatin) prompted us to study its effects on serum TSH, alpha-subunit, and free thyroid hormone (FT4 and FT3) concentrations in five patients with nIST and three patients with nnIST. During short term SMS 201-995 administration (100 micrograms, sc, three times daily for 5 days) both serum TSH and alpha-subunit levels decreased in all patients with nIST (mean decrements, -86% and -85%, respectively), with concomitant normalization of serum FT4 and FT3 concentrations. In the three patients with nnIST, this treatment lowered serum TSH levels less well (mean decrement, -47%), although serum FT4 and FT3 levels n...Continue Reading

Citations

Mar 20, 2003·Molecular and Cellular Endocrinology·Semi TascouPeter Burfeind
Apr 20, 1999·Endocrinology and Metabolism Clinics of North America·M E Shomali, L Katznelson
Apr 16, 1998·Endocrinology and Metabolism Clinics of North America·M T McDermott, E C Ridgway
Jan 1, 1992·Thyroid : Official Journal of the American Thyroid Association·I D Schwartz, B B Bercu
Jan 1, 1994·Thyroid : Official Journal of the American Thyroid Association·P Beck-Peccoz, V K Chatterjee
Mar 24, 1998·Thyroid : Official Journal of the American Thyroid Association·P GasparoniP Beck-Peccoz
Feb 1, 1994·Clinical Endocrinology·A W PatrickI A MacFarlane
Dec 19, 2006·Journal of Neurology, Neurosurgery, and Psychiatry·C DaousiI A MacFarlane
Sep 1, 1990·Postgraduate Medical Journal·A W ChanP M Foy
May 1, 1991·Postgraduate Medical Journal·S M OrmeP E Belchetz
Jul 9, 2010·The Journal of Clinical Endocrinology and Metabolism·Roy E WeissSamuel Refetoff
Dec 24, 1997·Journal of Pediatric Endocrinology & Metabolism : JPEM·F Darendeliler, F Baş
Jul 24, 2003·AJR. American Journal of Roentgenology·Nicholas J SarlisNicholas J Patronas
Jul 23, 2013·Frontiers in Neuroendocrinology·Marily Theodoropoulou, Günter K Stalla
Jan 23, 2016·Endocrine·Fatemeh G Amlashi, Nicholas A Tritos
Jan 27, 2005·Clinical Endocrinology·Deborah MannavolaPaolo Beck-Peccoz
Apr 1, 1993·The American Journal of Medicine·M T McDermott, E C Ridgway
May 20, 2008·Annales d'endocrinologie·F MoutonM-C Vantyghem
Jan 1, 1992·The American Journal of Medicine·A G WynneE Horvath
Dec 29, 2000·Thyroid : Official Journal of the American Thyroid Association·T J TaylorK D Burma
Jul 26, 2017·Clinical Endocrinology·Marlise E A van EerselGerrit van den Berg
Oct 12, 2019·International Journal of Molecular Sciences·Yu-Chin LiuKwang-Huei Lin
Mar 28, 2020·Thyroid : Official Journal of the American Thyroid Association·Rulai HanLei Ye
Mar 1, 1994·Clinical Endocrinology·C L MainiA Tofani
Feb 1, 1992·Journal of Endocrinological Investigation·A CrinòP Beck-Peccoz
Jun 1, 1997·Thyroid : Official Journal of the American Thyroid Association·M OzataM A Gündoğan
Jul 1, 1993·Journal of Endocrinological Investigation·M GasperiE Martino
Feb 4, 2010·Arquivos brasileiros de endocrinologia e metabologia·Felipe Henning Gaia DuarteMarcello Delano Bronstein
Jul 15, 2004·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·J R MulindaL I Rose
Sep 1, 1992·Metabolism: Clinical and Experimental·S Ezzat, S Melmed
Apr 1, 1994·Baillière's Clinical Endocrinology and Metabolism·V K Chatterjee, P Beck-Peccoz

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