Abstract
The effect of para-aminosalicylic acid-C (PAS-C, 8 g/day) on lipid metabolism was studied on a metabolic ward in nine subjects with primary endogenous hypertriglyceridemia. During 2 wk on a basal isocaloric liquid formula diet (40% fat, 45% carbohydrate), PAS-C reduced plasma triglyceride (-41.9 +/- 18.9%, p less than .01, -x +/- SD), cholesterol (-22.8 +/- 12.9%, p less than .005), and a very low density lipoprotein triglyceride (p less than .001) and cholesterol (p less than .01) levels without changing the cholesterol content of low density or high density lipoproteins. Similar effects occurred on a fat-free, 85% carbohydrate diet. Decreases in very low density lipoproteins correlated with changes in both total triglyceride (r = .99, p less than .01) and cholesterol (r = .70, p less than .05). Treatment with PAS-C reduced the plasma triglyceride removal rate related to lipoprotein lipase (-14.6 +/- 14.1%, p less than .02), but did not alter plasma postheparin lipolytic activity or the apparent Km for substrate-enzyme interaction. Kinetic data obtained during the prolonged heparin infusion fit the linearized Michaelis-Menten model for subjects with endogenous hypertriglyceridemia. The reduction in the plasma triglyceride conc...Continue Reading
References
Feb 1, 1976·Circulation·P T KuoK Hayase
Oct 1, 1976·Annals of Internal Medicine·W R Fisher, D H Truitt
Nov 1, 1977·Pediatriia·V A FursN V Pukhovskaia
Mar 1, 1978·Pediatrics·M J MalloyJ S Rowe
Sep 1, 1979·Metabolism: Clinical and Experimental·J D BrunzellE L Bierman
Jul 1, 1976·Annals of Internal Medicine·E H Ahrens
Jan 1, 1977·Advances in Experimental Medicine and Biology·R J Jones
Mar 11, 1976·The American Journal of Medicine·D Yeshurun, A M Gotto
Apr 1, 1971·The Journal of Clinical Endocrinology and Metabolism·L E BravermanS H Ingbar
May 1, 1972·The Journal of Clinical Investigation·D E Wilson, R S Lees
Aug 1, 1972·Annals of Internal Medicine
Nov 1, 1972·Atherosclerosis·L A CarlsonL Orö
Jul 1, 1973·The Journal of Clinical Investigation·W R HazzardE L Bierman
Jul 1, 1973·The Journal of Clinical Investigation·J D BrunzellE L Bierman
Jun 6, 1974·The New England Journal of Medicine·R I LevyB M Rifkind
Sep 1, 1974·Metabolism: Clinical and Experimental·R W StoutE L Bierman
Jul 1, 1973·Annals of Internal Medicine·R I LevyH R Sloan
Nov 1, 1974·Annals of Internal Medicine·P J BarterM A Newman
Jul 1, 1973·The Journal of Clinical Investigation·J L GoldsteinA G Motulsky
Mar 11, 1971·The New England Journal of Medicine·J D BrunzellE L Bierman
Oct 1, 1968·The American Journal of Medicine·E H StrisowerB Strisower
Dec 1, 1966·Diseases of the Chest·J M SchlessJ M Hale
Nov 1, 1967·The Journal of Clinical Investigation·G M ReavenJ W Farquhar
May 29, 1954·British Medical Journal·J A BALINTM G HANNO
Nov 6, 1954·Lancet·A G MACGREGOR, A R SOMNER
Nov 20, 1954·Lancet·D A EDWARDSW R TROTTER