Treatment of idiopathic oligozoospermia with recombinant human follicle-stimulating hormone: a prospective, randomized, double-blind, placebo-controlled clinical study in Chinese population

Clinical Endocrinology
Yin-Man DingXiao-Jun Shi

Abstract

Follicle-stimulating hormone plays a crucial role in spermatogenesis. The aim of this study was to evaluate the efficacy of treatment with FSH in Chinese infertility population. Prospective, randomized, double-blind, placebo-controlled clinical study. A total of 354 men affected by idiopathic oligozoospermia from three medical centres. This study contained three parts: (i) treatment with different doses of rhFSH (50 IU, 100 IU, 200 IU and 300 IU); (ii) the efficacy of rhFSH at different periods (2, 3, 4, 5 months); (iii) FSH treatment in patients with different levels of inhibin B (normal-level group, low-level group and high-level group). Semen parameters were evaluated in all subjects. The patients who had not reached spontaneous pregnancy underwent assisted reproductive techniques. Sperm number was significantly increased after treatment with FSH at doses of at least 200 IU, and the improvement was observed beginning at the third month. The significant improvement in both morphology and forward motility was observed beginning at the fifth month. Moreover, 300 IU rhFSH administration for 5 months could significantly improve the spontaneous pregnancy rate (12/40) and ART pregnancy rate (14/28), while the rates for placebo grou...Continue Reading

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Citations

Jan 20, 2017·Endocrine Journal·Koji Shiraishi, Hideyasu Matsuyama
Nov 9, 2018·Expert Opinion on Pharmacotherapy·Ylenia DucaSandro La Vignera
Dec 25, 2019·Andrology·Manuela Simoni, Daniele Santi
Mar 29, 2020·International Journal of Molecular Sciences·Livio CasariniManuela Simoni
Jul 6, 2019·Asian Journal of Andrology·Rossella CannarellaAldo E Calogero
May 7, 2020·The Journal of Clinical Endocrinology and Metabolism·Manuela SimoniLivio Casarini
Jan 9, 2019·Frontiers in Endocrinology·Olayiwola O OduwoleIlpo T Huhtaniemi
Jun 11, 2019·Frontiers in Endocrinology·Hermann M Behre
Mar 28, 2018·The Journal of Clinical Investigation·Olayiwola O OduwoleIlpo T Huhtaniemi
Mar 16, 2019·Frontiers in Endocrinology·Maria SchubertJörg Gromoll
May 20, 2020·Journal of Clinical Medicine·Maurizio De Rocco PonceAndrea Garolla

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